IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures
Todd W. Dowrey, Samuel F. Cranston, Nicholas J. Skvir, Yvonne Lok, Payton Bock, Elizabeth K. Kharitonova, Elise MacDonald, Ella Zeldich, Christopher V. Gabel, Alexander Tyshkovskiy, Stefano Monti, Vadim N. Gladyshev, Paola Sebastiani B, Thomas T. Perls, Stacy L. Andersen, George J. Murphy
The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.
bioRxiv · Oct 10, 2025 · PreprintMolecular Biology