Q. Zheng

This study identifies three Npl4 conformational states in the human p97 complex using cryo-EM and shows how a disulfiram derivative inhibits p97 by disrupting Npl4 zinc finger interactions.

This study identifies new regulatory patterns of KZFP family zinc fingers that drive their rapid evolution by binding non-transposable element regions and positively regulating gene expression.

This study identifies the COMPASS-like complex in M. oryzae and shows it regulates H3K4me3-mediated gene expression critical for fungal development and pathogenesis.

This study identifies an IRE1-dependent proinflammatory signaling pathway in glioblastoma that promotes tumor invasion, angiogenesis, and myeloid cell infiltration.

The paper creates an in situ atlas of mitochondrial DNA in mammalian tissues, revealing higher mtDNA content in stem/progenitor cells and age-related decreases in renal tubules.

This study shows PAD4 counteracts MGO-induced histone glycation by converting arginines to citrulline and removing glycation adducts, linking PAD4 to cancer progression.

The paper shows that constitutive IRE1 activation maintains differentiation in glioblastoma cells by repressing stemness factors.

This study investigates changes in mechanical properties and nanomorphology of BMSCs during early apoptosis using AFM and other techniques, finding that mechanical damage precedes apoptotic signals.

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

This study develops a finite element model of bilateral human semicircular canals to analyze cupular expansion and deflection during head rotation, showing their mechanical roles in vestibular function.

This study shows that antiseptic treatments cause short-term, personalized, and body site-specific changes in skin bacterial communities.

The paper uses NextRAD sequencing to infer movement of potato psyllids between host plants, identifying genetic similarities and differences that suggest potential new host species.