H. Xiong

Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic Nanovesicles

This study uses plasmonic nanovesicles to measure diffusion in GBM and finds the tumor margin has the lowest diffusion coefficient, indicating it acts as a diffusion barrier.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Microtubule binding-induced allostery promotes LIS1 dissociation from dynein prior to cargo transport

The paper investigates how microtubule binding affects LIS1 dissociation from dynein, showing that MT-bound dynein has low LIS1 affinity while MT-unbound dynein binds LIS1 strongly.

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

Optical Control Of Neuronal Activities With Photoswitchable Nanovesicles

This paper develops photoswitchable nanovesicles (azosomes) for precise optical control of molecular release in neurons, demonstrating their ability to activate dopamine receptors in cultured striatal neurons.

Optical Modulation of Blood-Brain-Tumor Barrier Permeability Enhances Drug Delivery in Diverse Preclinical Glioblastoma Models

This study demonstrates that optical modulation of the blood-brain-tumor barrier enhances drug delivery and suppresses tumor growth in glioblastoma models.

A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-Cov-2 virus and Omicron variant through a unique binding mode

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinum

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

Phytochrome B regulates reactive oxygen signaling during abiotic and biotic stress in plants

This study shows that phytochrome B regulates reactive oxygen species production during both abiotic and biotic stress in plants, working with RBOH proteins to control stress responses.

Multi-omics analysis for potential inflammation-related genes involved in tumor immune evasion via extended application of epigenetic data

The paper identifies STAT2 as a regulator of PD-L1 expression through multi-omics analysis and experimental validation, linking it to tumor immune evasion.

Azacytidine targeting SARS-CoV-2 viral RNA as a potential treatment for COVID-19

This study shows azacytidine limits SARS-CoV-2 infection and protects mice by disrupting viral RNA methylation.

The bundle sheath of rice is conditioned to play an active role in water transport as well as sulfur assimilation and jasmonic acid synthesis

The paper identifies gene expression patterns in rice bundle sheath cells, showing specialization in water transport, sulfur assimilation, and jasmonic acid synthesis, with conservation across C3 species.

Quantatitive Analysis of Conserved Sites on the SARS-CoV-2 Receptor-Binding Domain to Promote Development of Universal SARS-Like Coronavirus Vaccines

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

The long non-coding RNA MaTAR20 promotes mammary tumor growth by regulating angiogenesis pathways

This study identifies MaTAR20 as a lncRNA that promotes mammary tumor growth by regulating angiogenesis pathways, specifically through its interaction with Tnfsf15.

Sterilizing immunity against SARS-CoV-2 in hamsters conferred by a novel recombinant subunit vaccine

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

Robust neutralization assay based on SARS-CoV-2 S-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressed BHK21 cells

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

Endosperm development is an autonomously programmed process independent of embryogenesis

The paper shows that endosperm development in Arabidopsis occurs autonomously without embryo interaction, using single-fertilization mutants.

Virus-free and live-cell visualizing SARS-CoV-2 cell entry for studies of neutralizing antibodies and compound inhibitors

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

A Comprehensive Survey of Mutations in Oesophageal Carcinoma Reveals Recurrent Neoantigens as Potential Immunotherapy Targets

This study identifies recurrent neoantigens in esophageal carcinoma using mutation data from multiple sources, highlighting potential targets for immunotherapy.

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death

This study shows that immune dysregulation in SHARPIN-deficient mice depends on CYLD-mediated cell death, with CYLD inhibition leading to TNF-induced cell death and multi-organ inflammation.

Natural Variation of OsLG3 Controls Drought Stress Tolerance in Rice by Inducing ROS Scavenging

This study identifies natural variation in OsLG3 that enhances drought stress tolerance in rice by improving ROS scavenging, offering a genetic resource for breeding drought-tolerant rice.