Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Jia Duan, Dandan Shen, Tingting Zhao, Shimeng Guo, Xinheng He, Wanchao Yin, Peiyu Xu, Yujie Ji, Li-Nan Chen, Jinyu Liu, Huibing Zhang, Qiufeng Liu, Yi Shi, Xi Cheng, Hualiang Jiang, , Yi Jiang
The paper reports the structures of galanin bound to its receptors and G proteins, revealing the molecular basis for allosteric agonism and G protein subtype selectivity.
Nature Communications · Mar 15, 2022Peer-reviewedMolecular Biology