R. Cai

Physiological and metabolic insights into the first cultured anaerobic representative of deep-sea Planctomycetes bacteria

This study cultures a novel deep-sea Planctomycetes strain, characterizes its physiology and metabolism, and reveals nitrogen metabolism reprogramming by chronic bacteriophages.

Gene-by-environment interactions influence the fitness cost of gene copy-number variation in yeast

The paper investigates how gene copy-number variation (CNV) fitness costs vary with genetic background and environment in yeast, finding strain-specific responses to gene over-expression under NaCl stress.

Redefinition of archetypal phytoplankton-associated bacteria taxa based on globally distributed dinoflagellates and diatoms

The paper redefines phytoplankton-associated bacterial taxa at the genus level using data from diatoms and dinoflagellates, identifying core genera and their ecological roles in the phycosphere.

Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis

This study shows that lipid peroxidation during ferroptosis increases membrane tension, activates Piezo1 and TRP channels, and causes cation permeability, leading to cell death.

Efficacy of a Growth Hormone-Releasing Hormone Agonist in a Murine Model of Cardiometabolic Heart Failure with Preserved Ejection Fraction

This study tests the efficacy of GHRH agonist MR-356 in a murine model of cardiometabolic HFpEF, showing improvements in cardiac function and metabolic inflammation markers.

Cultivation and characterization of a novel clade of deep-sea Chloroflexi: providing a glimpse of the phylum Chloroflexi involved in sulfur cycling

The paper isolates and characterizes a novel Chloroflexi strain, showing its role in sulfur cycling through assimilatory sulfate reduction.

Characterization of the first cultured free-living representative of Candidatus Izimaplasma uncovers its unique biology

This study characterizes the first cultured free-living Candidatus Izimaplasma strain, revealing its unique DNA-degrading capabilities and ecological role in deep-sea methane seeps.

Bacteroidetes contribute to the carbon and nutrient cycling of deep sea through breaking down diverse glycans

The paper shows Bacteroidetes are key to deep-sea carbon and nutrient cycling by degrading diverse glycans through metagenomics, isolation, and transcriptomic/metabolomic analyses.

Activity of the GHRH Antagonist MIA602 and its Underlying Mechanisms of Action in sarcoidosis

This study investigates the anti-inflammatory effects of MIA602, a GHRH antagonist, in sarcoidosis by analyzing its impact on cytokine levels and cellular markers in vitro and in vivo.

Synthetic Agonist of Growth Hormone-Releasing Hormone as Novel Treatment for Heart Failure with Preserved Ejection Fraction

This paper tests a synthetic GHRH agonist, MR-356, in a mouse model of HFpEF, showing it prevents and reverses cardiac remodeling and dysfunction.

Heimdallarchaeota harness light energy through photosynthesis

The paper reports that Heimdallarchaeota, a group of archaea, possess proteins associated with photosynthesis and may perform oxygenic photosynthesis, suggesting a photomixotrophic lifestyle.

Metagenomic insights into the metabolism and ecologic functions of the widespread DPANN archaea from deep-sea hydrothermal vents

This study analyzes DPANN archaea from deep-sea hydrothermal vents to understand their metabolism and ecological roles, revealing their genomic features and potential contributions to biogeochemical cycles.

Cellular and Molecular Probing of Intact Transparent Human Organs

The paper introduces SHANEL, a method to clear and label stiff human organs for 3D histology, revealing structural details in intact adult human brain, kidney, and pig pancreas.

Deep learning reveals cancer metastasis and therapeutic antibody targeting in whole body

This paper introduces DeepMACT, a pipeline for automated detection of cancer metastases and therapeutic antibody targeting in whole-body mouse models using deep learning and enhanced imaging.