Author

X. Castro Dopico

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Organism:rat· 2 Assay:flow cytometry· 1

Frequent Co-Authors

B. Murrell· 3 shared C. Kim· 3 shared D. J. Sheward· 3 shared A. Pankow· 2 shared G. B. Karlsson Hedestam· 2 shared J. M. Coquet· 2 shared L. Hanke· 2 shared L. Perez Vidakovics· 2 shared

Activity by Year

2016-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

B. Murrell

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Author profile →

4 papers

Recent·Most cited

Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron)

D. J. Sheward, C. Kim, R. A. Ehling, A. Pankow, X. Castro Dopico, D. P. Martin, S. T. Reddy, J. Dillner, G. B. Karlsson Hedestam, J. Albert, B. Murrell

This study assesses neutralizing antibody responses against the SARS-CoV-2 Omicron variant, showing reduced potency compared to the pandemic founder but with some cross-neutralizing capacity in vaccinated individuals.

bioRxiv · Dec 19, 2021 · PreprintImmunology

Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost

D. J. Sheward, M. Mandolesi, E. Urgard, C. Kim, L. Hanke, L. Perez Vidakovics, A. Pankow, N. L. Smith, X. Castro Dopico, G. M. McInerney, J. M. Coquet, G. Karlsson Hedestam, B. Murrell

A single dose of a VOC-derived RBD protein boost enhances potent neutralizing antibodies against both Wu-Hu-1 and the VOC in previously vaccinated rhesus macaques.

bioRxiv · Apr 3, 2021 · PreprintImmunology

SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses

M. Mandolesi, D. J. Sheward, L. Hanke, J. Ma, P. Pushparaj, L. Perez Vidakovics, C. Kim, K. Lore, X. Castro Dopico, J. M. Coquet, G. McInerney, G. B. Karlsson Hedestam, B. Murrell

This study shows that SARS-CoV-2 spike protein subunit vaccines induce strong neutralizing antibodies in mice and macaques, with high titers after a single dose or dose-sparing regimen.

bioRxiv · Jul 31, 2020Immunology

Recent thymic emigrants produce antimicrobial IL-8, express complement receptors and are precursors of a tissue-homing Th8 lineage of memory cells

M. L. Pekalski, A. Rubio Garcia, R. C. Ferreira, D. B. Rainbow, D. J. Smyth, M. Mashar, J. Brady, N. Savinykh, X. Castro Dopico, S. Mahmood, S. Duley, H. E. Stevens, N. M. Walker, A. J. Cutler, F. Waldron-Lynch, , L. S. Wicker

The paper identifies CR2+ naive T cells as recent thymic emigrants that express antimicrobial IL-8 and complement receptors, and may become tissue-homing memory cells.

bioRxiv · Jun 17, 2016Immunology