Author

R. C. Wek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

W. J. Sullivan· 4 shared P. H. Amin· 3 shared J. Martynowicz· 2 shared K. R. Carlson· 2 shared L. Augusto· 2 shared M. J. Holmes· 2 shared A. J. Elmendorf· 1 shared A. J. Klunk· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMicrobiology

W. J. Sullivan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

mRNA cap-binding protein eIF4E1 is a novel regulator of Toxoplasma gondii latency

M. J. Holmes, M. S. Bastos, V. Dey, V. Severo, R. C. Wek, W. J. Sullivan

This study identifies eIF4E1 as a key regulator of Toxoplasma gondii latency by showing its role in translational control during encystation.

bioRxiv · Oct 9, 2023 · PreprintMicrobiology

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

R. Cordova, J. Misra, P. H. Amin, A. J. Klunk, N. P. Damayanti, K. R. Carlson, A. J. Elmendorf, K. Hyeong-Geug, E. T. Mirek, B. D. Elzey, M. J. Miller, X. C. Dong, L. Cheng, T. G. Anthony, R. Pili, , K. A. Staschke

This study shows GCN2 kinase supports prostate cancer growth by maintaining amino acid homeostasis, and a GCN2 inhibitor effectively reduces tumor growth in mouse models.

bioRxiv · Jun 17, 2022Cancer Biology

TgIF2K-B is an eIF2α kinase in Toxoplasma gondii that responds to oxidative stress and optimizes pathogenicity

L. Augusto, J. Martynowicz, P. H. Amin, K. R. Carlson, R. C. Wek, W. J. Sullivan

This study identifies TgIF2K-B as an eIF2α kinase in Toxoplasma gondii that mitigates oxidative stress and supports pathogenicity by enabling cyst formation and resisting macrophage activation.

bioRxiv · Sep 24, 2020Microbiology

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells

L. Augusto, J. Martynowicz, P. H. Amin, N. S. Alakhras, M. Kaplan, R. C. Wek, W. J. Sullivan

This study shows Toxoplasma gondii triggers the unfolded protein response in host cells to enhance migration and dissemination of infected cells through IRE1-mediated actin remodeling.

bioRxiv · Apr 14, 2020Microbiology

Simultaneous ribosome profiling of human host cells infected with Toxoplasma gondii

M. J. Holmes, P. Shah, R. C. Wek, W. J. Sullivan

This study uses ribosome profiling to analyze gene expression changes in Toxoplasma gondii and infected human cells, revealing translational control mechanisms and host response differences.

bioRxiv · Apr 26, 2019Microbiology