Author

K. La

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Garcia-Bermudez· 2 shared K. Birsoy· 2 shared A. Basu· 1 shared A. Ganesan· 1 shared A. Paulina Serrano· 1 shared A. Pimentel· 1 shared A. Vallmitjana· 1 shared B. Brooks· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

J. Garcia-Bermudez

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3 papers

Recent·Most cited

Glycosaminoglycan-mediated lipoprotein uptake protects cancer cells from ferroptosis

D. Calhoon, L. Sang, D. Bezwada, N. Kim, A. Basu, S.-C. Hsu, A. Pimentel, B. Brooks, K. La, A. Paulina Serrano, D. L. Cassidy, L. Cai, V. Toffessi-Tcheuyap, V. Margulis, F. Cai, , J. Garcia-Bermudez

This study identifies glycosaminoglycan-mediated lipoprotein uptake as a mechanism by which cancer cells resist ferroptosis and lipid oxidative stress.

bioRxiv · May 13, 2024Cancer Biology

Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis

T. Vu, A. Vallmitjana, J. Gu, K. La, Q. Xu, J. Flores, J. Zimak, J. Shiu, L. Hosohama, J. Wu, C. R. Douglas, M. Waterman, A. Ganesan, P. N. Hedde, E. Gratton, W. Zhao

This paper introduces MOSAICA, a spatial transcriptomics technology that combines spectral and lifetime encoding with machine learning to enable highly multiplexed in situ biomarker profiling.

bioRxiv · Jun 22, 2021Bioengineering

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

J. Garcia-Bermudez, S. Prasad, L. Baudrier, M. A. Badgley, Y. Liu, K. La, M. Soula, R. T. Williams, N. Yamaguchi, R. F. Hwang, L. J. Taylor, E. De Stanchina, B. Rostandy, H. Alwaseem, H. Molina, , K. Birsoy

The paper identifies GOT2-catalyzed mitochondrial aspartate synthesis as essential for pancreatic tumor cell proliferation under hypoxia, but this dependency is bypassed by hypoxia-induced macropinocytosis.

bioRxiv · Feb 2, 2021Cancer Biology