Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy
J. F. Ehrmann, D. B. Grabarczyk, M. Heinke, L. Deszcz, R. Kurzbauer, O. Hudecz, A. Shulkina, R. Gogova, A. Meinhart, G. A. Versteeg, T. Clausen
The paper determines the cryo-EM structure of BIRC6 and its complex with HTRA2 and SMAC, revealing how SMAC inhibits BIRC6 to regulate apoptosis and autophagy.
bioRxiv · Aug 30, 2022 · PreprintBiochemistry