R. Orchard

Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB

The paper identifies JADE3 as an antiviral activator of the NF-kB pathway through a CRISPR activation screen against influenza A virus.

Norovirus MLKL-like pore forming protein initiates programed cell death for viral egress

This study identifies a mechanism by which norovirus induces cell death and egress through an MLKL-like pore-forming protein that targets mitochondria.

A FACT-ETS-1 Antiviral Response Pathway Restricts Viral Replication and is Countered by Poxvirus A51R Proteins

This study identifies a FACT-ETS-1 antiviral pathway that restricts poxvirus replication and shows how viral A51R proteins counteract it.

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

This study identifies NPC1 and endosomal cholesterol homeostasis as critical for reovirus penetration into the cytoplasm, but not for attachment, internalization, or disassembly.

Identification of anti-norovirus genes in mouse and human cells using genome-wide CRISPR activation screening

This study identifies 57 host genes that inhibit murine norovirus replication in mouse or human cells using CRISPR activation screening, revealing novel antiviral mechanisms.