T. S. Dermody

Structure of Orthoreovirus RNA Chaperone σNS, a Component of Viral Replication Factories

This paper determines the structure of the reovirus σNS RNA chaperone and shows how its oligomeric state and N-terminal arm regulate RNA binding and chaperone activity.

A gut commensal protist protects against virus-mediated loss of oral tolerance

This study identifies the protist Tritrichomonas arnold as a protector against virus-induced loss of oral tolerance to gluten, showing it reduces inflammation in dendritic cells and is underrepresented in celiac disease patients.

Chikungunya virus vaccine candidate incorporating synergistic mutations is attenuated and protects against virulent virus challenge

This study evaluates a Chikungunya virus vaccine candidate with synergistic mutations that enhance safety and induce neutralizing antibodies in mice.

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

This study identifies NPC1 and endosomal cholesterol homeostasis as critical for reovirus penetration into the cytoplasm, but not for attachment, internalization, or disassembly.

The human neuronal receptor NgR1 bridges reovirus capsid proteins to initiate infection

This study identifies how NgR1 bridges reovirus capsid proteins to initiate infection, revealing a unique binding interface and its role in virus entry and receptor ligand interactions.

The Murine Neuronal Receptor NgR1 Is Dispensable for Reovirus Pathogenesis

This study shows that NgR1 is not required for reovirus pathogenesis in mice, suggesting other receptors mediate CNS tropism.

The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation to allow viral replication and myocardial injury

This study identifies σ3 as a reovirus virulence factor that suppresses PKR activation and stress granule formation, linking these functions to viral replication and myocardial injury in mice.

Reovirus σ1 conformational flexibility modulates the efficiency of host cell attachment

This study shows that conformational flexibility of reovirus σ1 protein affects host cell attachment efficiency by engineering cysteine mutations that alter σ1 structure.