Author

R. P. van Rij

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Evolutionary Biology· 1

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:Arabidopsis· 5 Research Focus:cell type annotation· 5 Organism:Drosophila· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

G. J. Overheul· 5 shared P. Miesen· 5 shared M. Vermeulen· 3 shared B. Besson· 2 shared F. S. Varghese· 2 shared J. Joosten· 2 shared J. Qu· 2 shared O. M. Lezcano· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersMicrobiology

G. J. Overheul

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Author profile →

9 papers

Recent·Most cited

Pan-flavivirus analysis reveals sfRNA-independent, 3'UTR-biased siRNA production from an Insect-Specific Flavivirus

B. Besson, G. J. Overheul, M. T. Wolfinger, S. Junglen, R. P. Van Rij

The paper compares siRNA profiles of mosquito-borne and insect-specific flaviviruses, finding 3'UTR-biased siRNA production in insect-specific viruses like Kamiti River virus, independent of sfRNA.

Journal of Virology · Nov 19, 2024Peer-reviewedMicrobiology

Parallel evolution and enhanced virulence upon in vivo passage of an RNA virus in Drosophila melanogaster

O. M. Lezcano, L. Fuhrmann, G. Ramakrishnan, N. Beerenwinkel, M. Huynen, R. P. van Rij

This study shows that RNA virus evolution under host immune pressure leads to parallel mutations in a specific viral protein, increasing virulence and replication efficiency across different host genotypes.

bioRxiv · Jul 21, 2023 · PreprintMicrobiology

The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells

J. Qu, M. Schinkel, L. Chiggiato, S. Rosendo Machado, G. J. Overheul, P. Miesen, R. P. van Rij

The paper identifies the Hsf1-sHsp cascade as a pan-antiviral mechanism in mosquito cells, effective against multiple arboviruses.

bioRxiv · Feb 21, 2023Microbiology

Arbovirus-vector protein interactomics identifies Loquacious as a co-factor for dengue virus replication in Aedes mosquitoes

B. Besson, O. M. Lezcano, G. J. Overheul, K. Janssen, C. G. Spruijt, M. Vermeulen, J. Qu, R. P. Van Rij

The paper identifies Loquacious as a mosquito host factor essential for dengue and Zika virus replication, revealing its role in viral RNA replication independent of RNAi activity.

bioRxiv · Feb 4, 2022Microbiology

Berberine and obatoclax inhibit SARS-CoV-2 replication in primary human nasal epithelial cells in vitro

F. S. Varghese, E. van Woudenbergh, G. J. Overheul, M. J. Eleveld, L. Kurver, N. van Heerbeek, A. van Laarhoven, P. Miesen, G. den Hartog, M. I. de Jonge, R. P. van Rij

bioRxiv · Dec 23, 2020Microbiology

Immunity to infections in arboviral vectors by integrated viral sequences: an evolutionary perspective

C. Crava, F. S. Varghese, E. Pischedda, R. Halbach, U. Palatini, M. Marconcini, A. Mattia, S. N. Redmond, Y. Afrane, D. Ayala, C. Paupy, R. Carballar-Lejarazu, P. Miesen, R. P. van Rij, M. Bonizzoni

The paper shows that nonretroviral endogenous viral elements (nrEVEs) in Aedes aegypti confer antiviral immunity by producing piRNAs, supporting their role as heritable immunity effectors.

bioRxiv · Apr 2, 2020 · PreprintEvolutionary Biology

Non-retroviral endogenous viral element limits cognate virus replication in Aedes aegypti ovaries

Y. Suzuki, A. Baidaliuk, P. Miesen, L. Frangeul, A. B. Crist, S. H. Merkling, A. Fontaine, S. Lequime, I. Moltini-Conclois, H. Blanc, R. P. van Rij, L. Lambrechts, M.-C. Saleh

The paper shows that a non-retroviral EVE in Aedes aegypti limits replication of its cognate virus, CFAV, through piRNA-mediated antiviral activity in ovaries.

bioRxiv · Mar 28, 2020Microbiology

The Tudor protein Veneno assembles the ping-pong amplification complex that produces viral piRNAs in Aedes mosquitoes

J. Joosten, P. Miesen, B. Pennings, P. W. T. C. Jansen, M. A. Huynen, M. Vermeulen, R. P. Van Rij

The paper identifies Veneno, a Tudor protein in Aedes aegypti, as essential for viral piRNA production via its role in assembling the ping-pong amplification complex with Ago3 and Piwi5.

bioRxiv · Aug 15, 2018Microbiology

Induction and suppression of NF-κB signalling by a DNA virus of Drosophila

W. H. Palmer, J. Joosten, G. J. Overheul, P. W. Jansen, M. Vermeulen, D. J. Obbard, R. P. Van Rij

This study investigates how a Drosophila DNA virus, Kallithea virus, interacts with the insect immune system, identifying gp83 as a Toll pathway inhibitor.

bioRxiv · Jun 29, 2018Microbiology