R. Xu

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

This study identifies INS1 as a protease critical for macrogamont formation and oocyst production in Cryptosporidium parvum, with loss of INS1 reducing virulence in mice.

This paper develops a pyrF-based genetic manipulation system for Acinetobacter baumannii, enabling efficient marker-less gene editing in multiple strains.

The paper investigates how structural dynamics in bilobed proteins evolve, showing that modifications to the structural core enable functional diversification through altered interdomain interactions and substrate specificity.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

This study shows that CHMP5 regulates bone formation by controlling endolysosome-mitochondrion-mediated cell senescence, and targeting senescent cells can alleviate musculoskeletal abnormalities.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

This study investigates the intestinal absorption of morroniside using a Caco-2 cell model, finding pH- and temperature-dependent transport and involvement of efflux proteins.

This paper develops a DNA methylation-based deep neural network model to predict cancer origins with high accuracy across multiple datasets and cancer types.

This study shows that IKKε, a breast cancer oncogene, reprograms mitochondrial function and serine metabolism independently of its canonical signaling role, promoting cancer cell proliferation.

The paper investigates how E7820 recruits RBM39 to the DCAF15 E3 ligase complex through structural and kinetic analysis, revealing its mechanism as a molecular glue.

This study shows that FXR deficiency increases liver damage and inflammation during ischemia-reperfusion injury, with altered bile acid metabolism and gut microbiota composition.

This study investigates the catalytic mechanism of ACER3, identifying key residues and demonstrating its Zn2+-dependent activity similar to other Zn-based amidases.