P. Liang

Enhancing Whole Slide Image Classification with Discriminative and Contrastive Learning

This study improves whole slide image classification by using discriminative and contrastive learning to create WSI-level positive and negative samples, enhancing classification performance and feature robustness.

TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids

This study shows that OSCA/TMEM63 proteins, like TMEM16s, can permeate ions and phospholipids, highlighting conserved functional potential across the TCS superfamily.

Long noncoding RNA Hottip maintained skeletal homeostasis via suppressing the enhancer of zeste homolog 2 (Ezh2)/histone methylation regulatory axis

This study identifies Hottip as a regulator of skeletal homeostasis by suppressing the Ezh2/histone methylation axis, affecting osteoblast and osteoclast differentiation.

Endothelial TMEM16F lipid scramblase regulates angiogenesis

This study identifies TMEM16F as a regulator of angiogenesis through intracellular signaling, showing impaired retinal angiogenesis in TMEM16F-deficient mice and altered VE-cadherin and Src kinase activity in human endothelial cells.

Niclosamide potentiates TMEM16A and induces vasoconstriction

This study shows niclosamide potentiates TMEM16A and induces vasoconstriction, challenging its use as a TMEM16A inhibitor for asthma and COPD.

Phosphoregulation of the Rad51 auxiliary factor Swi5-Sfr1

This study shows that phosphorylation of Sfr1 in the Swi5-Sfr1 complex regulates its interaction with Rad51, affecting DNA repair efficiency in yeast.

An ULK1/2-PXN mechanotransduction complex suppresses breast cancer cell migration

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.

Trophoblast organoids with physiological polarity model placental structure and function

The paper develops trophoblast organoids with physiological polarity to model placental structure and function, showing improved hormone secretion and syncytium size.

PXN/Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling

This study shows that PXN phase separation drives focal adhesion assembly and integrin signaling through light-inducible manipulation.

Gut microbiota assemblages of generalist predators are driven by local- and landscape-scale factors

This study examines how environmental factors shape spider gut microbiota composition using high-throughput sequencing, identifying local and landscape-scale drivers.

Transcellular progression of infection threads in Medicago truncatula roots is controlled by locally confined cell wall modifications

The paper investigates how rhizobia move through Medicago truncatula root cells by analyzing the role of SyPME and NPL in cell wall modifications during infection thread progression.

DNA metabarcoding of gut contents reveals key habitat and seasonal drivers of trophic networks involving generalist predators in agricultural landscapes

This study uses DNA metabarcoding to analyze gut contents of spiders in agricultural landscapes, revealing how environmental factors influence their trophic interactions and diet composition.

Protection from Omicron and other VOCs by Bivalent S-Trimer COVID-19 Vaccine

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

Remorin proteins serve as membrane topology scaffolds in plants

The paper shows remorin proteins stabilize membrane tubules and curvature during symbiotic infections in plants.

Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

The paper shows TRPV4 activates TMEM16F in trophoblasts, promoting cell fusion, and identifies this as a mechanism for syncytialization and disease-related fusion.

Broad neutralization against SARS-CoV-2 variants induced by a modified B.1.351 protein-based COVID-19 vaccine candidate

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

Cryo-EM structure of S-Trimer, a subunit vaccine candidate for COVID-19

The paper determines the Cryo-EM structures of S-Trimer variants for COVID-19 vaccine development, showing they adopt a tightly closed conformation similar to the full-length S protein.

Laser induced isolation and cultivation of single microbial cells

This paper demonstrates a laser-induced cell sorting technique that isolates and cultivates single microbial cells with viability, achieving varying recovery rates across different species.

A formin-mediated cell wall- plasma membrane- cytoskeleton continuum is required for symbiotic infections in Medicago truncatula

This study identifies SYFO1, a formin protein in Medicago truncatula, which connects the cell wall and cytoskeleton to facilitate rhizobial infection by enabling plasma membrane remodeling and cell polarization.

Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

Molecular underpinning of intracellular pH regulation on TMEM16F

This study identifies how intracellular pH regulates TMEM16F's lipid scrambling and ion channel activities through Ca2+ binding site protonation and deprotonation.

Identification and characterization of retro-DNAs, a new type of retrotransposons originated from DNA transposons, in primate genomes

This study identifies retro-DNAs, a new type of non-LTR retrotransposon derived from DNA transposons, in primate genomes, showing they use the L1 TPRT mechanism and may impact gene function.

Comparative genomics analysis reveals high levels of differential DNA transposition among primates

This study identifies species-specific mobile elements in eight primate genomes, revealing significant variation in DNA transposition activity and subfamily dominance across species.

Contribution of mobile elements to the uniqueness of human genome with more than 15,000 human-specific insertions

The paper identifies 15,463 human-specific mobile elements (HS-MEs) contributing to genome size increase and gene regulation, expanding prior knowledge by over 8,000 elements.

Na/K pump: Single-channel vs. Two-access-channel

The paper re-examines Na/K pump currents, finding that two-directional charge movement currents become uni-directional under high stimulation, suggesting a single-channel configuration.

Symbiotic root infections in Medicago truncatula require remorin-mediated receptor stabilization in membrane nanodomains

The paper shows that remorin and SYMREM1 stabilize LYK3 in membrane nanodomains, which is essential for successful symbiotic root infections in Medicago truncatula.