The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI
Armando M. Marrufo, Jonathan J. Molina, Christopher Gager, Marissa Jeme Andersen, Alyssa Ann La Bella, Elizabeth R. Lucas, Ellsa Wongso, Tamanna Urmi, Kassandra Arias-Parbul, Railyn Webster, Peter V. Stuckey, Kurt N. Kohler, Deborah L. Donahue, Victoria A. Ploplis, Matthew J. Flick, , Ana Lidia Flores‐Mireles
This study shows that fibrin accumulation in a catheterized bladder promotes anti-inflammatory macrophage polarization, which impairs antimicrobial responses and allows bacterial persistence in UTIs.
bioRxiv · Jul 16, 2024 · PreprintImmunology