Author

Victoria A. Ploplis

University of Notre DameORCID 0000-0002-6506-764XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Francis J. CastellinoiD· 2 shared Alyssa Ann La BellaiD· 1 shared Ana Lidia Flores‐MirelesiD· 1 shared Armando M. MarrufoiD· 1 shared Christopher GageriD· 1 shared Deborah L. DonahueiD· 1 shared Elizabeth R. LucasiD· 1 shared Ellsa Wongso· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPathology

Francis J. CastellinoORCID

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2 papers

Recent·Most cited

Coagulation factor XII contributes to renin activation, heart failure progression, and mortality

Inna P. Gladysheva, Ryan D. Sullivan, Sofiyan Saleem, Francis J. Castellino, Victoria A. Ploplis, Guy L. Reed

The paper identifies coagulation factor XII as a driver of renin activation, contributing to heart failure progression and mortality.

bioRxiv · Sep 6, 2024 · PreprintPathology

The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI

Armando M. Marrufo, Jonathan J. Molina, Christopher Gager, Marissa Jeme Andersen, Alyssa Ann La Bella, Elizabeth R. Lucas, Ellsa Wongso, Tamanna Urmi, Kassandra Arias-Parbul, Railyn Webster, Peter V. Stuckey, Kurt N. Kohler, Deborah L. Donahue, Victoria A. Ploplis, Matthew J. Flick, , Ana Lidia Flores‐Mireles

This study shows that fibrin accumulation in a catheterized bladder promotes anti-inflammatory macrophage polarization, which impairs antimicrobial responses and allows bacterial persistence in UTIs.

bioRxiv · Jul 16, 2024 · PreprintImmunology