1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway
Yi-Ting Tsai, Nicolas-Frédéric Lipp, Olivia Seidel, Riya Varma, Aurélie Laguerre, Kristina Solorio-Kirpichyan, Adrian M. Wong, Roberto J. Brea, Grace H. McGregor, Thekla Cordes, Neal K. Devaraj, Lars Kuerschner, Sonya E. Neal, Christian M. Metallo, Itay Budin
This study investigates how 1-deoxysphingolipids affect membrane properties and cargo trafficking in the early secretory pathway by analyzing their subcellular distribution and effects on ER membrane fluidity and ERES.
Cell chemical biology · Jan 1, 2026Peer-reviewedCell Biology