This study shows that HIV Env endocytosis affects cleavage status and antibody neutralization, with uncleaved Env increasing sensitivity to certain antibodies in cell-to-cell infection.

Journal of Virology · May 28, 2026Peer-reviewedMicrobiology

HIV-1 infection is associated with depletion of germinal center B cells and a decrease in IgA+ plasma cells in the GI tract

Francesca Cossarini, Joan Shang, Azra Krek, Zainab Al-Taie, Ruixue Hou, Pablo Canales-Herrerías, Minami A. Tokuyama, Michael Tankelevich, Adam Tillowitz, Divya Jha, Alexandra E. Livanos, Louise Leyre, Mathieu Uzzan, Gustavo Martínez-Delgado, Matthew D. Taylor, , Saurabh Mehandru

Science Immunology · Oct 25, 2024Peer-reviewedImmunology

HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model

Alice K. Min, Behnam Javidfar, Roy D. Missall, Donald Doanman, Madel Durens, Samantha St Vil, Zahra Masih, Mara Graziani, Annika Mordelt, Samuele G. Marro, Lot D. de Witte, Benjamin K. Chen, Talia H. Swartz, Schahram Akbarian

This paper describes a humanized mouse model using iPSC-derived microglia to study HIV-1 infection in the CNS, enabling genetic and therapeutic investigations in vivo.

Journal of Virology · Nov 30, 2023Peer-reviewedNeuroscience

HIV integration in the human brain is linked to microglial activation and 3D genome remodeling

Amara L. Plaza-Jennings, Aditi Valada, Callan P. O’Shea, Marina Iskhakova, Benxia Hu, Behnam Javidfar, Gabriella Ben Hutta, Tova Y. Lambert, Jacinta Murray, Bibi S. Kassim, Sandhya Chandrasekaran, Benjamin K. Chen, Susan Morgello, Hyejung Won, Schahram Akbarian

The paper examines HIV integration in the human brain using single nuclei transcriptomics, Hi-C, and IS-seq, finding 3D genomic reorganization and microglial activation linked to HIV infection.

Molecular Cell · Dec 1, 2022Peer-reviewedNeuroscience