Author

W. M. Henne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 8 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 6 Assay:proteomics· 5 Research Focus:development & morphogenesis· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Approach:microscopy & imaging analysis· 3 Organism:yeast· 3

Frequent Co-Authors

B. Paul· 4 shared A. Kovalenko· 3 shared N. O. Speer· 3 shared D. Nicastro· 2 shared E. Reetz· 2 shared E. Reynolds· 2 shared H. Hariri· 2 shared H. Merta· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersCell Biology

B. Paul

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Author profile →

9 papers

Recent·Most cited

Paraoxonase-like APMAP maintains endoplasmic reticulum-associated lipid and lipoprotein homeostasis

B. Paul, H. Merta, R. Ugrankar-Banerjee, M. Hensley, S. Tran, G. Dias do Vale, J. G. McDonald, S. A. Farber, W. M. Henne

This paper identifies APMAP as an ER-localized antioxidant that maintains lipid and lipoprotein homeostasis, with loss of APMAP causing ER stress, lipid droplet accumulation, and altered lipoprotein maturation across multiple organisms.

bioRxiv · Jan 26, 2024Cell Biology

Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration

H. Merta, T. Isogai, B. Paul, G. Danuser, W. M. Henne

The paper maps the human ER subdomain proteome, identifies CLMN as an ER-actin tether at focal adhesions, and shows it promotes cell migration by regulating actin dynamics and calcium signaling.

bioRxiv · Jan 24, 2024Cell Biology

Tld1 is a novel regulator of triglyceride lipolysis that demarcates a lipid droplet subpopulation

N. O. Speer, R. J. Braun, E. Reynolds, A. Brudnicka, J. Swanson, W. M. Henne

The paper identifies Tld1 as a regulator of triglyceride lipolysis that specifically targets TG-rich lipid droplets and modulates lipolysis in yeast.

bioRxiv · Mar 7, 2023Cell Biology

The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipose cell size

R. Ugrankar-Banerjee, S. Tran, J. Bowerman, A. Kovalenko, B. Paul, W. M. Henne

This study shows that Act5C-dependent cortical actin networks in Drosophila fat body regulate adipose cell size, lipid trafficking, and signaling during development.

bioRxiv · Jun 15, 2022Cell Biology

Triglyceride lipolysis driven by glucose restriction triggers liquid-crystalline phase transitions and proteome remodeling of lipid droplets

S. Rogers, L. Gui, A. Kovalenko, V. Zoni, M. Carpentier, K. Ramji, K. Ben Mbarek, A. Bacle, P. Fuchs, P. Campomanes, E. Reetz, N. O. Speer, E. Reynolds, A. R. Thiam, S. Vanni, , W. M. Henne

The paper shows glucose restriction induces liquid-crystalline phase transitions in lipid droplets by promoting TG lipolysis, which alters lipid composition and remodels the proteome.

bioRxiv · Apr 15, 2022Cell Biology

Structural predictions of the SNX-RGS proteins suggest they belong to a new class of lipid transfer proteins

B. Paul, S. Weeratunga, V. A. Tillu, H. Hariri, W. M. Henne, B. Collins

The paper uses AlphaFold2 to predict the structure of SNX-RGS proteins, revealing a new class of lipid transfer proteins with a conserved hydrophobic pocket.

bioRxiv · Nov 30, 2021Biochemistry

ER-localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation

M. O. Gok, N. O. Speer, W. M. Henne, J. R. Friedman

The paper identifies ER-localized phosphatidylethanolamine synthase (Psd1) as a novel regulator of lipid droplet formation, showing its conserved role across species.

bioRxiv · Aug 31, 2021Cell Biology

Liquid-crystalline lipid phase transitions in lipid droplets selectively remodel the LD proteome

S. Rogers, L. Gui, A. Kovalenko, E. Reetz, D. Nicastro, W. M. Henne

The paper shows glucose restriction induces liquid-crystalline lipid phase transitions in lipid droplets, which selectively remodel the LD proteome and affect ER-LD transport.

bioRxiv · Aug 30, 2021 · PreprintCell Biology

Vacuole-specific lipid release for tracking intracellular lipid metabolism and transport in Saccharomyces cerevisiae

V. Girik, S. Feng, H. Hariri, W. M. Henne, H. Riezman

The paper develops a method to release lipids from the vacuole in yeast to study lipid metabolism and transport, showing Mdm1 facilitates sphingoid base to ceramide conversion and cholesterol can restore cell proliferation under sterol deprivation.

bioRxiv · May 4, 2021Cell Biology