B. Paul

SREBP governs a triglyceride:glycogen metabolic switch in Drosophila

This paper shows that blocking lipid synthesis in Drosophila fat body triggers a metabolic switch to glycogen storage, mediated by SREBP and HATs, supporting development but reducing lifespan and fecundity.

A large attachment organelle mediates interaction between a novel Nanobdellota archaeon YN1 and its host

This study isolates and characterizes a novel Nanobdellota archaeon and its host, revealing an attachment organelle that mediates their ectosymbiotic interaction.

Paraoxonase-like APMAP maintains endoplasmic reticulum-associated lipid and lipoprotein homeostasis

This paper identifies APMAP as an ER-localized antioxidant that maintains lipid and lipoprotein homeostasis, with loss of APMAP causing ER stress, lipid droplet accumulation, and altered lipoprotein maturation across multiple organisms.

Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration

The paper maps the human ER subdomain proteome, identifies CLMN as an ER-actin tether at focal adhesions, and shows it promotes cell migration by regulating actin dynamics and calcium signaling.

In-depth characterisation of a selection of gut commensal bacteria reveals their functional capacities to metabolise dietary carbohydrates with prebiotic potential

This study examines the metabolic capacities of gut commensal bacteria toward prebiotic carbohydrates, revealing strain-specific effects on metabolite production and gene expression.

Reduced male fertility of an Antarctic mite following extreme heat stress could prompt localized population declines

This study shows that extreme heat stress reduces male fertility in Antarctic mites, potentially leading to population declines.

The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipose cell size

This study shows that Act5C-dependent cortical actin networks in Drosophila fat body regulate adipose cell size, lipid trafficking, and signaling during development.

Structural predictions of the SNX-RGS proteins suggest they belong to a new class of lipid transfer proteins

The paper uses AlphaFold2 to predict the structure of SNX-RGS proteins, revealing a new class of lipid transfer proteins with a conserved hydrophobic pocket.

Cas12a is a dynamic and precise RNA-guided nuclease without off-target activity on {lambda}-DNA

This study investigates Cas12a's DNA binding and cleavage mechanisms using optical tweezers and fluorescence, showing it cleaves only the target site without off-target activity on λ-DNA.

DeepFRET: Rapid and automated single molecule FRET data classification using deep learning

DeepFRET automates smFRET data classification using deep learning, achieving >95% accuracy and speed compared to human operators.