S. Abuhattum

Estimation of the mass density of biological matter from refractive index measurements

This paper estimates mass density from refractive index measurements using a method that incorporates biochemical composition assumptions and uncertainty analysis, validated on biological samples.

Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens

This study investigates how adipocyte shape, size, and lipid accumulation affect mechanical properties of adipose tissue in health, obesity, and diabetes.

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

This paper introduces a microfluidic method to measure viscoelastic properties of suspended cells using shear flow deformation cytometry and demonstrates cell cycle-dependent rheological behavior.

De novo identification of universal cell mechanics gene signatures

This study identifies a conserved gene module involved in cell mechanics regulation using a mechanomics approach combining mechanical characterization and machine learning analysis of transcriptomic data.

Correlative all-optical quantification of mass density and mechanics of sub-cellular compartments with fluorescence specificity

This paper introduces FOB microscopy to measure sub-cellular density and mechanics with fluorescence specificity, revealing differences between nucleoplasm and cytoplasm.

Using real-time fluorescence and deformability cytometry and deep learning to transfer molecular specificity to label-free sorting

Buckling of epithelium growing under spherical confinement

This study demonstrates that epithelial monolayers growing under spherical confinement can fold through buckling, showing forces and elastic properties drive the shape change.

Zebrafish spinal cord repair is accompanied by transient tissue stiffening

This study measures tissue stiffness changes in zebrafish spinal cord during repair, finding transient stiffening that correlates with cellular and structural changes.

Intracellular mass density increase is accompanying but not sufficient for stiffening and growth arrest of yeast cells

The paper shows that increased intracellular mass density correlates with stiffness in yeast cells during metabolic arrest but is not sufficient for growth arrest.

Standardized microgel beads as elastic cell mechanical probes

This paper presents standardized poly-acylamide microgel beads as mechanical probes for cell mechanics, showing they can be calibrated to mimic cell elasticity and used for cross-comparison of measurement techniques.