S. Adhikari

The Early Dodder Gets the Host: Decoding the Coiling Patterns of Cuscuta campestris with Automated Image Processing

This study uses automated image processing to analyze coiling patterns of Cuscuta campestris and finds that coiling efficacy varies with inoculation time of day.

Agrobacterium-mediated Cuscuta campestris transformation as a tool for understanding plant-plant interactions

This paper develops a stable Agrobacterium-mediated transformation protocol for Cuscuta campestris, enabling transgenic plant generation and insights into molecular trafficking during parasitism.

An Integrated Machine Learning Approach Delineates an Entropic Expansion Mechanism for the Binding of a Small Molecule to α-synuclein

This study uses machine learning to show that fasudil modulates α-synuclein's conformational states through entropic expansion, offering insights into small molecule interactions with IDPs.

CNC Knitting Micro-Resolution Mosquito Bite Blocking Textiles

The paper designs micro-resolution knitted textiles produced by robotic manufacturing to block mosquito bites and protect against vector-borne diseases.

Computational Design of Two New Vitamin K Epoxide Reductase Inhibitors

This study designs two new VKOR inhibitors using computational methods, predicting improved ADMET and binding properties over existing drugs.

Longitudinal in vivo changes in radial peripapillary capillaries and optic nerve head structure in non-human primates with early experimental glaucoma

This study tracks changes in radial peripapillary capillaries and optic nerve head structure in non-human primates with early experimental glaucoma, finding that RPC density often changes before retinal nerve fiber layer thinning.

Characterizing Locus Specific Chromatin Structure and Dynamics with Correlative Conventional and Super Resolution imaging in living cells

This study develops a correlative imaging approach to analyze chromatin structure and dynamics in living cells with single molecule precision, revealing insights into locus-specific chromatin behavior.

A Recombinant Protein Biomarker DDA Library Increases DIA Coverage of Low Abundance Plasma Proteins

The paper develops a recombinant protein biomarker library to improve DIA coverage of low abundance plasma proteins, identifying 20 previously undetected proteins using SWATH-MS.

Computational design of two new soluble epoxide hydrolase (sEH) inhibitors

This study computationally designs two new soluble epoxide hydrolase (sEH) inhibitors with improved pharmacokinetic properties and docking scores compared to t-TUCB.

Computationally Guided Design of Novel Selective Serotonin Reuptake Inhibitors

This study designs two novel SSRIs with better docking scores than paroxetine using computational methods and identifies mice as a suitable preclinical model.

Quantitative live-cell PALM reveals nanoscopic Faa4 redistributions and dynamics on lipid droplets during metabolic transitions of yeast

This study uses PALM to show Faa4 redistributes and increases in density on yeast lipid droplets during metabolic transitions, with changes linked to expression levels and lipolysis.

Gene regulatory networks associated with lateral root and nodule development in soybean

The paper develops a computational framework to predict gene regulatory networks (GRNs) associated with lateral root and nodule development in soybean, identifying key transcription factors and co-regulated modules.

Unraveling the mechanism of the cadherin-catenin-actin catch bond

The paper presents a theoretical model explaining the catch bond mechanism in the cadherin-catenin-actin complex, identifying energy barriers and their role in force regulation.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.