S. Alonso

De-glycosylated non-structural protein 1 enhances dengue virus clearance by limiting PD-L1/PD-1 mediated T cell apoptosis

This study shows that de-glycosylation of N207 in DENV NS1 reduces viral fitness and enhances clearance by limiting PD-L1/PD-1 mediated T cell apoptosis.

Enterovirus-A71 exploits Rab11 to recruit chaperones for virus morphogenesis

This study identifies Rab11 as a host factor exploited by EV-A71 to recruit chaperones for virus morphogenesis, independent of its role in trafficking or replication.

Single shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad and durable systemic and mucosal immune responses

This study evaluates a SARS-CoV-2 vaccine candidate that targets dendritic cells, showing durable systemic and mucosal immune responses against multiple variants.

A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection.

This study identifies a γδ IEL hyperproliferative phenotype influenced by the intestinal microbiota, which enhances protection against bacterial infection.

Somatic hypomethylation of pericentromeric SST1 repeats and tetraploidization in human colorectal cancer cells

The paper links SST1 hypomethylation with tetraploidization in human colorectal cancer cells and associates severe SST1 demethylation with TP53 mutations in primary CRC.

Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique

The paper measures antibody transfer from HIV-infected mothers to infants in Mozambique and finds HIV reduces placental transfer of IgG and IgG1 antibodies against pathogens and vaccine antigens.

HflX controls hypoxia-induced non-replicating persistence in slow growing mycobacteria

This study shows HflX in slow-growing mycobacteria enables hypoxia-induced non-replicating persistence, contributing to drug tolerance and dormancy.

Relative contribution of non-structural protein 1 in dengue pathogenesis

This study shows that NS1 does not play a critical role in pathogenesis of certain DENV2 strains, suggesting NS1 may not be a universal vaccine candidate.