Author

K. L. Edelblum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:imaging· 1

Frequent Co-Authors

I. Prinz· 2 shared L. Jia· 2 shared N. B. Golovchenko· 2 shared A. Fong· 1 shared A. J. M. Watson· 1 shared A. Lemenze· 1 shared A. S. Chawla· 1 shared C. J. Anderson· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersImmunology

I. Prinz

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Author profile →

5 papers

Recent·Most cited

Type I interferon induces TCR-dependent and -independent antimicrobial responses in γδ intraepithelial lymphocytes

M. A. Fischer, L. Jia, K. L. Edelblum

This study shows type I interferon induces antimicrobial responses in γδ IELs both independently and dependently on TCR signaling.

bioRxiv · Mar 11, 2024 · PreprintImmunology

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn's disease-like ileitis

W. Xu, N. B. Golovchenko, A. Fong, S. Achi, E. B. Bucar, K. J. Vidmar, L. Zhang, M. R. Frey, I. Prinz, T. T. Pizarro, G. Kollias, K. L. Edelblum

This study identifies dysregulation of γδ intraepithelial lymphocytes (IELs) before the onset of Crohn's disease-like ileitis in a mouse model.

bioRxiv · Aug 31, 2023Immunology

Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection

A. S. Chawla, M. Vandereyken, M. Arias, L. Santiago, D. Dikovskaya, C. Nguyen, N. Skariah, N. Wenner, N. Golovchenko, S. Thomson, E. Ondari, M. Garzon-Tituana, C. J. Anderson, M. Bergkessel, J. C. D. Hinton, , M. Swamy

This study shows that granzymes A and B use distinct cell death pathways to protect against intestinal Salmonella infection by balancing bacterial growth and translocation.

bioRxiv · Nov 7, 2021Immunology

A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection.

L. Jia, G. Wu, S. Alonso, C. Zhao, A. Lemenze, Y. Y. Lam, L. Zhao, K. L. Edelblum

This study identifies a γδ IEL hyperproliferative phenotype influenced by the intestinal microbiota, which enhances protection against bacterial infection.

bioRxiv · Jul 22, 2021Immunology

γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release.

M. D. Hu, N. B. Golovchenko, T. J. Kelly, J. Agos, M. R. Zeglinski, E. M. Bonder, I. Sandrock, I. Prinz, D. J. Granville, A. J. M. Watson, K. L. Edelblum

This study identifies γδ intraepithelial lymphocytes as facilitators of pathological epithelial cell shedding through CD103-mediated granzyme release in response to LPS.

bioRxiv · Jan 20, 2021Immunology