S. Eaton

Single cell-guided prenatal derivation of primary epithelial organoids from the human amniotic and tracheal fluids.

The paper derives epithelial organoids from human amniotic and tracheal fluids to model congenital malformations and predict disease outcomes.

Prenatal VEGF Nano-Delivery Reverses Congenital Diaphragmatic Hernia-Associated Pulmonary Abnormalities

This paper investigates VEGF supplementation as a treatment for congenital diaphragmatic hernia (CDH)-associated lung abnormalities using an ex vivo model and nanoparticle-based delivery in vivo.

Active shape programming drives Drosophila wing disc eversion

The paper shows active cellular behaviors drive 3D shape changes in Drosophila wing disc pouch through spontaneous strains, validated by MyoVI knockdown.

The incidence of movement disorders increases with age and contrasts with subtle and limited neuroimaging abnormalities in argininosuccinic aciduria.

This study investigates movement disorders in argininosuccinic aciduria (ASA), finding they increase with age and show specific neuroimaging abnormalities not seen in mouse models.

SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids

This paper shows that SARS-CoV-2 can infect and replicate in pediatric gastric organoids but not in fetal ones, suggesting differential susceptibility based on developmental stage.

Apico-basal cell compression regulates Lamin A/C levels in Epithelial tissues

This study shows that Lamin A/C concentration in epithelial tissues scales with apico-basal cell compression, independent of ECM, and is regulated by nuclear deformation.

Engineering transplantable jejunal mucosal grafts using primary patient-derived organoids from children with intestinal failure

This study develops a method to create transplantable jejunal mucosal grafts using patient-derived organoids and decellularized scaffolds, demonstrating functional grafts in vitro and in vivo.

Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity

The paper investigates Rab-mediated trafficking in Drosophila male accessory gland secondary cells and finds Rab6 is essential for their function and female post-mating behavior.