S. Ji

Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

This study evaluates cipargamin's efficacy against Babesia species and identifies resistance mechanisms, showing its effectiveness as an anti-babesial drug but limitations due to resistance, with combination therapy with tafenoquine offering potential.

GABA production induced by imipridones is a targetable and imageable metabolic alteration in diffuse midline gliomas

This study shows imipridones induce GABA accumulation in diffuse midline gliomas, which can be used for non-invasive imaging and therapy.

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

Insight into the genetic diversity, resistance, and virulence of Listeria from the marine environment: reveal the risk of hypervirulent isolates

This study examines Listeria species in beach sand, identifying hypervirulent isolates and their potential role in human listeriosis.

Instar determination by constrained gaussian mixture models according to Dyar's rule

This paper develops constrained Gaussian mixture models based on Dyar's rule to accurately determine insect instars from morphometric data.

Two Competing Guilds as a Core Microbiome Signature for Health Recovery

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

ASER: Animal Sex Reversal database

ASER compiles sex reversal data from 18 species, including genes, regulatory networks, RNA-seq, and ISH images, to support research on animal breeding and human health.

Homeostasis Equation: An Approach to Theoretical Medicine

This paper introduces an integral equation to model homeostasis in living organisms and demonstrates its ability to quantitatively represent various biological situations.

Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states

The paper investigates the expression and regulation of isolated 3'UTRs (i3UTRs) across development and cell states, finding distinct patterns and functional roles in gene regulation.

Genes influencing phage host range in Staphylococcus aureus on a species-wide scale

This paper identifies genes in Staphylococcus aureus that influence phage host range by analyzing strain sensitivity to phages and associating genome sequences with host range.

Fundamental contribution and host range determination of ANP32 protein family in influenza A virus polymerase activity

This study identifies ANP32A and ANP32B as essential for influenza A virus polymerase activity, showing species-specific roles and mutations affecting viral replication.

Dimethylarsenic acid (DMA) accumulation positively correlates with realgar-induced subchronic toxicity in rats

This study shows that dimethylarsenic acid (DMA) accumulation correlates with realgar-induced toxicity in rats, with liver and kidney damage reversing after drug withdrawal.