W. Kamitani

Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms

This study develops a live-attenuated SARS-CoV-2 vaccine candidate, BK2102, which induces long-term immunity and is safe in animal models.

Versatile live attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

This study develops a live attenuated SARS-CoV-2 vaccine platform using temperature-sensitive mutations that provides protection against homologous and heterologous viral challenges.

Reverse Genetics with a Full-length Infectious cDNA Clone of Bovine Torovirus

This paper develops a reverse genetics system for bovine torovirus using a full-length infectious cDNA clone, demonstrating the effects of genetic manipulations on viral growth and gene stability.

Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction

This study develops a PCR-based reverse genetics system for SARS-CoV-2 using CPER to generate infectious clones with high accuracy and titer.

The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting viral replication-transcription complex in culture cells

This paper identifies ciclesonide as an inhaled corticosteroid that inhibits SARS-CoV-2 replication by targeting the viral replication-transcription complex in cultured cells.

The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15

The paper identifies ciclesonide as a corticosteroid that inhibits coronavirus replication by targeting NSP15, with resistance emerging through an amino acid substitution.