H. Hasegawa

Understanding the biosynthesis of human IgMs through a combinatorial expression of mutant subunits that affect different assembly steps

This study investigates IgM biosynthesis by analyzing mutant subunits affecting disulfide bonds, revealing the role of non-covalent interactions in IgM assembly and secretion.

Use of the particle agglutination/particle agglutination-inhibition test for antigenic analysis of SARS-CoV-2

This study develops a PA/PAI test to rapidly assess SARS-CoV-2 antigenicity using hACE2-bound latex beads, showing it can detect antigenic differences between variants.

Impact of reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters

This study investigates reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters, finding that immunity prevents pneumonia but allows viral replication in the upper airways with increased mutation diversity.

Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology

This study shows that an intranasal vaccine with CpG ODN2006 induces secretory IgA antibodies against SARS-CoV-2 variants and reduces lung eosinophilic immunopathology compared to subcutaneous vaccination.

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

The peripheral T cell population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus 2

This study shows that cynomolgus monkeys with lower peripheral T cell counts experience more severe pneumonia after SARS-CoV-2 infection compared to those with higher T cell counts.

Suberoyl bis-hydroxamic acid reactivates Kaposis sarcoma-associated herpesvirus through histone acetylation and induces apoptosis in lymphoma cells

This paper shows that SBHA reactivates KSHV in PEL cells through histone acetylation and induces apoptosis via the mitochondrial pathway, suggesting its potential as a therapeutic for PEL.

Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

This study develops a forecasting framework for influenza A/H3N2 evolution by integrating phenotypic antigenic drift data with sequence-based fitness estimates, showing improved long-term predictions.