S. Rao

The paper investigates mutational processes in colorectal cancer resistance to anti-EGFR antibodies, finding that mutational Signature 17 predicts resistance evolution and shorter progression-free survival.

This study compares additive and polarizable models in MD simulations of the 5HT3 receptor channel to assess their impact on water and ion behavior in nanopores.

This study identifies KDM6B-dependent chromatin remodelling as critical for virus-specific CD8+ T cell differentiation and memory formation.

The paper determines the structures of CALHM1 and CALHM2 using cryo-EM and shows their unique oligomeric assembly and lipid interactions.

This study shows that cytoplasmic ARID1B promotes pancreatic cancer by activating RAF-ERK signaling and β-catenin transcription.

This study presents Cryo-EM structures of full-length glycine receptors in different functional states, revealing conformational changes and validating their function through molecular dynamics simulations.

This study shows that blue light sensed by OPN3 in adipocytes regulates thermogenesis and lipolysis in mice.

The paper introduces CHAP, a computational tool that predicts hydrophobic gates in ion channel structures using molecular dynamics simulations to improve functional annotation.

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

The paper develops a heuristic model to predict hydrophobic gates in ion channels using radius and hydrophobicity data from molecular dynamics simulations and machine learning.

This study identifies a novel signaling loop involving ADAMDEC1 and FGF2/FGFR1 that maintains glioblastoma cancer stem cells and shows targeting this loop reduces tumor growth.

This paper develops a cross-species personalized medicine pipeline using canine sarcomas to identify new treatments, finding proteasome inhibitors initially effective but limited by tumor heterogeneity.

This study evaluates cyclosporine's efficacy and side effects in treating chronic hepatitis in dogs, finding it effective with no negative factors identified.

The paper analyzes genomic and transcriptomic data from CRC patients treated with cetuximab to identify resistance mechanisms and immune landscape changes during anti-EGFR therapy.

The paper establishes a baseline human gut microbiota profile and provides a reference database and reporting tool for clinical and research applications.

The paper identifies N-terminal degradation as the mechanism for Nlrp1b inflammasome activation, leading to caspase-1 activation and pyroptotic cell death.