Author

J. Sonnenburg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 6 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:metagenomics· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3

Frequent Co-Authors

E. Sonnenburg· 3 shared F. B. Yu· 3 shared K. C. Huang· 3 shared S. Higginbottom· 3 shared A. Violette· 2 shared B. H. Good· 2 shared D. Dahan· 2 shared D. Perelman· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

E. Sonnenburg

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Author profile →

9 papers

Recent·Most cited

Improved mouse models of the small intestine microbiota using region-specific sampling from humans

R. Culver, S. P. Spencer, A. Violette, E. Lemus Silva, T. Takeuchi, C. Nafarzadegan, S. Higginbottom, D. Shalon, J. Sonnenburg, K. C. Huang

The paper develops improved mouse models of the small intestine microbiota using region-specific human intestinal sampling and in vitro culturing, showing increased diversity and reproducibility in colonization.

bioRxiv · Apr 24, 2024 · PreprintMicrobiology

A mutant fitness compendium in Bifidobacteria reveals molecular determinants of colonization and host-microbe interactions

A. L. Shiver, J. Sun, R. Culver, A. Violette, C. Wynter, M. Nieckarz, S. P. Mattiello, P. K. Sekhon, L. Friess, H. K. Carlson, D. Wong, S. K. Higginbottom, M. Weglarz, W. Wang, B. D. Knapp, , K. C. Huang

The paper creates a mutant fitness compendium for Bifidobacterium breve to identify molecular factors affecting colonization and host-microbe interactions.

bioRxiv · Aug 29, 2023 · PreprintMicrobiology

Impact of a 7-day homogeneous diet on interpersonal variation in human gut microbiomes and metabolomes

L. Guthrie, S. Spencer, D. Perelman, W. Van Treuren, S. Han, F. B. Yu, E. Sonnenburg, M. A. Fischbach, T. W. Meyer, J. Sonnenburg

A 7-day homogeneous diet did not reduce interindividual variation in uremic microbiome-derived metabolites, indicating limited dietary impact and suggesting the need for microbial interventions.

bioRxiv · Oct 29, 2021Microbiology

Gut Microbiota-Targeted Diets Modulate Human Immune Status

H. C. Wastyk, G. K. Fragiadakis, D. Perelman, D. Dahan, B. D. Merrill, F. B. Yu, M. Topf, C. Gonzalez, J. L. Robinson, J. E. Elias, E. Sonnenburg, C. D. Gardner, J. Sonnenburg

This study examines how plant-based fiber and fermented food diets affect the gut microbiome and immune system in healthy adults over 17 weeks.

Cell · Aug 1, 2021Peer-reviewedMicrobiology

Clostridium difficile exploits a host metabolite produced during toxin-mediated infection

J. Sonnenburg, K. Pruss

This study shows Clostridium difficile uses host-derived sorbitol, produced during toxin-mediated inflammation, as a nutrient source.

bioRxiv · Jan 14, 2021Microbiology

Quantifying the interplay between rapid bacterial evolution within the mouse intestine and transmission between hosts

K. S. Vasquez, L. Willis, N. Cira, K. M. Ng, M. F. Pedro, A. Aranda-Diaz, M. Rajendram, F. B. Yu, S. K. Higginbottom, N. Neff, G. Sherlock, K. B. Xavier, S. Quake, J. Sonnenburg, B. H. Good, K. C. Huang

The paper tracks bacterial evolution and transmission in mice using barcoded E. coli strains, showing rapid selection and migration effects on microbiota composition.

bioRxiv · Dec 4, 2020Microbiology

Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations

K. M. Pruss, A. Marcobal, A. Southwick, D. Dahan, S. Smits, J. Ferreyra, S. Higginbottom, E. Sonnenburg, P. Kashyap, B. Choudhury, L. Bode, J. Sonnenburg

The paper shows that mucin-derived O-glycans can restore microbiota balance and improve host health by promoting beneficial microbes and suppressing pathogens.

bioRxiv · Jun 9, 2020Microbiology

Depletion of microbiome-derived molecules in the host using Clostridium genetics

C.-J. Guo, B. Allen, K. Hiam, D. Dodd, W. van Treuren, S. Higginbottom, C. Fischer, J. Sonnenburg, M. Spitzer, M. Fischbach

This study develops a genetic method to disable Clostridium species and investigates the impact of microbiome-derived molecules on host IgA modulation.

bioRxiv · Aug 27, 2018Microbiology

Gut microbiome transition across a lifestyle gradient in Himalaya

A. R. Jha, E. R. Davenport, Y. Gautam, D. Bhandari, S. Tandukar, K. Ng, S. Holmes, G. P. Gautam, J. B. Sherchand, C. Bustamante, J. Sonnenburg

The paper examines gut microbiome differences across four Himalayan populations with varying lifestyles, finding that microbiome composition is significantly associated with lifestyle changes rather than genetics or geography.

bioRxiv · Jan 27, 2018Microbiology