A. N. Calabrese

A targetable N-terminal motif orchestrates α-synuclein oligomer to fibril conversion

This study identifies an N-terminal motif in α-synuclein oligomers that drives fibril conversion and shows how a mutation disrupts this process, offering a new therapeutic target.

Tension mediated mechanical activation and pocket delipidation lead to an analogous MscL state

This study investigates how tension and pocket delipidation affect MscL channel states, finding they lead to similar expanded states but through different pathways.

Structural basis of rotavirus RNA chaperone displacement and RNA annealing

This study identifies how the rotavirus NSP2 protein regulates RNA chaperone activity through structural changes that promote RNA annealing and release.

PyXlinkViewer: a flexible tool for visualisation of protein chemical crosslinking data within the PyMOL molecular graphics system

PyXlinkViewer maps XL-MS data onto protein structures and models, enabling visualization and analysis of crosslinks and inter-residue distances.

Inter-domain dynamics in the chaperone SurA and multi-site binding to its unfolded outer membrane protein clients

This study investigates the conformational dynamics of SurA and its interaction with unfolded OMP clients using multiple biophysical techniques.

Structural insight into the formation of lipoprotein-β-barrel complexes by the β-barrel assembly machinery

The paper reports the crystal structure of BamA in complex with RcsF, revealing a push-and-pull mechanism for RcsF export and providing insights into BAM function and antibiotic development.

Stability of local secondary structure determines selectivity of viral RNA chaperones

This study compares the ability of viral RNA chaperones NSP2 and σNS to promote inter-segment RNA-RNA interactions, finding that NSP2's high affinity for structured RNAs and efficient helix disruption enable successful inter-segment association, while σNS lacks this capacity.