S. Zhang

This paper presents a deformable microfluidic device using microbeads to separate plasma and retrieve blood cells, supported by imaging and computational modeling.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

This study shows that mechanical forces in Vibrio cholerae biofilms drive a reorientation cascade, creating a core-rim structure through differential growth and compressive stresses.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study uses long-read sequencing to show DNA methylation affects pre-mRNA splicing, poly(A) tail length, and gene silencing in Arabidopsis.

The paper identifies antiviral drugs by analyzing RNA-host protein interactomes of SARS-CoV-2, EBOV, and ZIKV.

WRKY33 regulates indole glucosinolate biosynthesis and hydrolysis, enhancing resistance to Alternaria brassicicola in Arabidopsis and Brassica crops.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

This study identifies PcDHCR7 in Phytophthora capsici as a {bigtriangleup}7-sterol reductase essential for mycelium development and pathogenicity.

ClustENMD efficiently samples biomolecular conformational space using a hybrid method combining elastic network models and molecular dynamics simulations.

This study identifies HSPD1 as a therapeutic target in NSCLC, showing its disruption leads to metabolic breakdown and suppressed tumor growth.

This paper presents a hardware-software solution for co-registering photoacoustic tomography and MRI images in vivo, demonstrating hybrid-contrast imaging of tumor microenvironments.

This study shows that young and undamaged recombinant mouse serum albumin (rMSA) extends the lifespan and healthspan of C57BL/6N mice by 17.6% and 20.3% respectively.

This study identifies EZH2's role in promoting breast cancer bone metastasis through the integrin β1-FAK pathway and TGFβ signaling.

The paper identifies hyperactive antibody responses and vascular pathology in metabolic-active lung tissues of tuberculosis patients, sharing features with autoimmune diseases.

This study identifies CTPS1 as a target for antiviral therapy by showing it suppresses interferon induction and promotes viral replication in SARS-CoV-2 infection.

Eliglustat inhibits autophagy in osteoclasts, reducing MM bone disease and suggesting its use as a treatment for bone loss disorders.

This study shows that XIST knockdown reduces cell proliferation and increases apoptosis in diabetic cataract by regulating the miR-34a/SMAD2 axis.

This study shows that lauric acid intake leads to endogenous production of DLPC, an LRH-1 ligand, and enhances LRH-1 transcriptional activity in multiple tissues.

This study models O2 transport in tissue during magnetic needle acupuncture and finds that magnetic fields enhance interstitial flow and O2 delivery, particularly in permeable tissues.

This study identifies SiCEP3, a C-terminally encoded peptide from Setaria italica, which promotes ABA import and signaling by inhibiting receptor kinase activity under abiotic stress.

This study shows prior SARS-CoV-2 infection in golden hamsters provides partial protection but not sterilizing immunity, and virus can still be transmitted between infected and naive animals through direct contact.

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

This study shows that inhaled anesthetics reduce neural excitability by disrupting multiple-water entanglement networks, which amplify hydroxide ion concentration changes.

This paper evaluates the contribution of fluid movement to oxygen transport in tissue using a physical-phenomenological model, showing its significance in O2-deficient regions and cytoplasm movement.

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

The paper identifies and characterizes a novel adipocyte population with active Wnt/β-catenin signaling that influences beige fat formation and glucose homeostasis in mice.

This study identifies metabolic reprogramming in ibrutinib-resistant DLBCL using multi-omics integration, revealing the BTK-PI3K-AKT-IL4I1 axis as a key driver of drug resistance.

This study shows Hsp70 chaperones TDP-43 in liquid-like phase, preventing its aggregation and maintaining dynamic nuclear bodies under stress.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.