S. Zhang

The paper investigates the origin of the SARS-CoV-2 Omicron variant, finding evidence suggesting it jumped from humans to mice and then back to humans.

This study profiles healthy human kidney cells from 19 donors to reveal sex-based transcriptional differences and tissue-specific immune features.

The paper introduces WESTPA 2.0, an upgraded software package for weighted ensemble simulations, enhancing efficiency and analysis of longer-timescale applications.

The paper investigates two CLas effectors, P235 and Effector 3, showing they suppress citrus innate immune responses and contribute to HLB pathogenesis by inhibiting immune proteins and inducing cell death.

This study shows that reducing dermal white adipose tissue (dWAT) worsens EGFR inhibitor-induced skin rash in mice, and activating PPARγ with rosiglitazone improves skin function without affecting antitumor effects.

The paper uses molecular dynamics simulations to analyze how three imidazoquinoline agonists selectively bind to TLR7 and TLR8, revealing van der Waals interactions as key to their selectivity.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

This study shows that PD-L1 palmitoylation affects its membrane orientation and immune evasion by altering its localization and interaction with PD-1 on T cells.

This paper develops a method using clustered gas vesicles and spectral imaging to enable multiplexed ultrasound imaging for visualizing different species of gas vesicles at the single-cell level.

This study develops 3D human brown adipose microtissues that improve glucose and insulin homeostasis in obese and diabetic mice.

The paper screens synthetic peptides for enhancing nutrient uptake in plants, finding that CEP1 increases nitrate, phosphate, and sulfate uptake in Medicago and Arabidopsis.

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

The paper identifies sex differences in glutamine metabolism in glioblastomas, showing male tumors have higher glutamine uptake and are more sensitive to GLS1 inhibition than female tumors.

This study investigates how Schistosoma mansoni eggs interact biomechanically with vascular endothelial cells to facilitate their extravasation from blood vessels.

This study reveals the dynamic regulation of USP14 and proteasome through cryo-EM structures and time-resolved analysis, identifying three regulatory checkpoints in proteasome function.

This study identifies CaMYB101 as an anthocyanin biosynthesis repressor in pepper through genome-wide R2R3-MYB analysis and virus-induced gene silencing.

This paper shows that GspB scaffolds the T2SS secretin pore in Dickeya dadantii by anchoring it to the inner membrane and peptidoglycan, and identifies its conserved periplasmic domain and interactions with GspD.

This study identifies early megakaryocyte lineage-committed progenitors in adult mouse bone marrow and proposes a differentiation model involving intermediate progenitors.

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

The paper shows that increasing cell size remodels the proteome and promotes senescence, but polyploidization can prevent this by altering the DNA-to-ploidy ratio.

This study shows that co-exposure to pesticides and streptomycin in E. coli leads to stronger antibiotic resistance with lower fitness costs and persistence after selective pressure removal.

This study identifies KPNB1 and RUVBL2 as key regulators of NFAT5's unconventional tonicity-dependent nuclear trafficking.

This paper identifies GASA6 as a non-antibiotic selectable marker for plant transformation, demonstrating its effectiveness in tobacco through growth and regeneration on sugar-free media.

The paper uses live imaging to show that timing of meristem transitions in fern gametophytes affects their morphology.

The study identifies a secondary metabolite produced by L. reuteri that mediates intraspecies antagonism, with resistance linked to cell wall acetylation.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

The paper quantifies how two alternative promoters of the Bicoid target gene hunchback are differentially regulated by Bcd through enhancer-promoter interactions in Drosophila embryos.

The paper identifies early antibody responses that predict COVID-19 severity and vaccine response, showing functional differences in inflammation regulation.

This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.