Molecular mechanisms underlying amyloid lowering by aducanumab: differential and comparative effects of sex and IgG reveal the post-treatment disease brain
Kathryn A. Haynes, Ravi S. Pandey, Emma H. Doud, Zackary A. Cope, Gabriela J. Little, Sean-Paul Williams, Umesh Nepali, Sara K. Quinney, Ankit Nagar, Nitin Charbe, Lais Da Silva, Jeffrey L. Dage, Duc M. Duong, Nicholas T. Seyfried, Michael Sasner, , Stacey J. Sukoff Rizzo
This study examines the molecular effects of aducanumab treatment in 5XFAD mice, revealing sex-dependent and IgG-mediated changes in amyloid and associated pathways.
bioRxiv · Jun 21, 2026 · PreprintNeuroscience