Ronald Petrus Albertus Gaykema

Gene therapy with doxycycline-controlled expression of human Kv1.1 reduces neuronal excitability and increases sociability of Scn2a-deficient mice

This study shows that inducing Kv1.1 expression in Scn2a-deficient mice reduces neuronal hyperexcitability and improves sociability without affecting wild-type mice.

Seizures induce c-fos expression in a subset of astrocytes, termed fostrocytes, that dampen subsequent seizures

The paper identifies a subset of astrocytes, called fostrocytes, that express c-fos after seizures and show anti-seizure effects when their activity is increased.

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

Microglia play beneficial roles in multiple experimental seizure models.

This study demonstrates that microglia have a beneficial role in reducing various types of seizures using a targeted approach.

DNA Methyltransferase 1 and 3a Expression in the Frontal Cortex Regulates Palatable Food Consumption

This study shows that deleting DNA methyltransferase 1 and 3a in the mouse prefrontal cortex reduces palatable food consumption without affecting chow intake, with effects on neuron excitability and DNA methylation patterns.