Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade
Andrew J. Snyder, Sarah M. Garrison, Mitchell G. Kluesner, W. Sam Nutt, Carolyn Shasha, T. T. Giang Ho, Sydney A. Marsh, Miles Hamilton Linde, Feinan Wu, Lauren K. Meyer, Amelia R. Wilhelm, Sergio Ortiz‐Espinosa, Victor Zepeda, Emma Bingham, Haleema S. Malik, , Shivani Srivastava
This study shows that overexpressing c-Jun in CAR-T cells enhances their ability to maintain PD-1+Tcf1+ stem-like cells in tumors and improves response to PD-L1 blockade.
Science Immunology · Mar 6, 2026Peer-reviewedImmunology