Author

Si-Yu Wang

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 1

Frequent Co-Authors

Subhash C. SinhaiD· 2 shared Abulimiti AikedaniD· 1 shared Guillermo Coronas‐SamanoiD· 1 shared Hagen TilgneriD· 1 shared Hongmin LiiD· 1 shared Jingjie ZhuiD· 1 shared Ke CheniD· 1 shared Kendra Norman· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Subhash C. SinhaORCID

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2 papers

Recent·Most cited

Identification and characterization of UBA5 inhibitors

Vigyasa Singh, Yuansong Wan, Zhisong Gao, Tahsin Reaz Ahmed, Si-Yu Wang, Ke Chen, Subodh Kumar Samrat, Zhong Li, Subhash C. Sinha, Li Gan, Hongmin Li

This study identifies five novel UBA5 inhibitors through HTS, showing selectivity and efficacy in inhibiting UFMylation, with potential for therapeutic applications in neurodegenerative diseases and cancer.

ACS Chemical Biology · Aug 17, 2026Peer-reviewedBiochemistry

cGAS inhibition delays TDP-43-driven ALS Pathogenesis

Yajing Liu, Weixi Feng, Abulimiti Aikedan, Se-In Lee, Maitreyee Bhagwat, Ravi Kumar Nagiri, Man Ying Wong, Sadaf Amin, Wenhui Qu, Jingjie Zhu, Si-Yu Wang, Pearly Ye, Kendra Norman, Guillermo Coronas‐Samano, Marta Olah, , Li Gan

This study identifies cGAS as a key mediator of TDP-43 pathology in ALS and shows that its inhibition reduces RNA splicing defects and neurodegeneration.

bioRxiv · Feb 26, 2026 · PreprintNeuroscience