Author

Siyan Zhu

West Virginia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Neuroscience· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Jianhai DuiD· 3 shared Artjola PujaiD· 2 shared Peng ZouiD· 2 shared Rachel McNeel· 2 shared Rong XuiD· 2 shared Adam E. CoheniD· 1 shared Bo LiiD· 1 shared Bo WangiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

Jianhai DuORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Aging Differentially Remodels the Retina and RPE/Choroid Proteome and Metabolism

Siyan Zhu, Artjola Puja, Rachel McNeel, Diana Alabdallat, Tuan Ngo, Jianhai Du

This study identifies age-related proteomic and metabolic changes in the retina and RPE/Cho of mice, revealing tissue-specific and age-dependent shifts in metabolic pathways.

bioRxiv · Oct 9, 2026 · PreprintBiochemistry

Early proteomic signatures of Alzheimer`s disease in the retina and brain of 3xTg-AD mice

Artjola Puja, Rachel McNeel, Rong Xu, Siyan Zhu, David Hansman, Jianhai Du

This study identifies early proteomic changes in the retina and brain of 3xTg-AD mice, revealing shared and tissue-specific metabolic and transport dysregulation linked to Alzheimer's disease.

Frontiers in Cell and Developmental Biology · May 18, 2026Peer-reviewedBiochemistry

A Palette of Bridged Bicycle-Strengthened Fluorophores

Junwei Zhang, Kecheng Zhang, Kui Wang, Bo Wang, Siyan Zhu, Hongping Qian, Yumiao Ma, Mengling Zhang, Tianyan Liu, Peng Chen, Yuan Shen, Yunzhe Fu, Shilin Fang, Xinxin Zhang, Peng Zou, , Zhixing Chen

This paper introduces a new class of fluorophores with enhanced photostability, solubility, and tunable properties for advanced biological imaging applications.

Nature Methods · May 19, 2025Peer-reviewedBiophysics

Solaris: a panel of bright and sensitive hybrid voltage indicators for imaging membrane potential in cultured neurons

Junqi Yang, Siyan Zhu, Luming Yang, Luxin Peng, Yi Han, Rebecca Frank Hayward, Pojeong Park, Dachao Hu, Adam E. Cohen, Peng Zou

The paper introduces Solaris, a hybrid voltage indicator with improved sensitivity for imaging membrane potential in cultured neurons.

bioRxiv · Feb 2, 2024 · PreprintNeuroscience

Metabolic features of mouse and human retinas: rods vs. cones, macula vs. periphery, retina vs. RPE

Bo Li, Ting Zhang, Wei Liu, Yekai Wang, Rong Xu, Shaoxue Zeng, Rui Zhang, Siyan Zhu, Mark C. Gillies, Ling Zhu, Jianhai Du

The paper identifies metabolic differences between mouse and human retinas, cones vs. rods, macula vs. periphery, and retina vs. RPE, highlighting distinct metabolic pathways and nutrient exchange.

iScience · Oct 14, 2020Peer-reviewedNeuroscience