Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells
M. B. Barnkob, Y. S. Michaels, V. Andre, P. S. Macklin, U. Gileadi, S. Valvo, M. Rei, C. Kulicke, J.-L. Chen, V. Jain, V. Woodcock, H. Colin-York, A. V. Hadjinicolaou, Y. Kong, V. Mayya, , V. Cerundolo
This study shows Sema3A inhibits tumor-specific CD8+ T cell function by inducing cytoskeletal paralysis via NRP1 in the tumor microenvironment.
bioRxiv · Nov 20, 2019Immunology