Author

T. B. Poulsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

D. Olagnier· 4 shared E. B. Svenningsen· 4 shared C. K. Holm· 2 shared M. Idorn· 2 shared S. R. Paludan· 2 shared A. Alcami· 1 shared A. E. K. E. Kiib· 1 shared A. E. Kiib· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMicrobiology

D. Olagnier

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

F. H. Waqas, M. Shehata, W. A. M. Elgaher, A. Lacour, N. Kurmasheva, F. Begnini, A. E. K. E. Kiib, J. Dahlmann, C. Chen, T. B. Poulsen, S. Merkert, U. Martin, R. Olmer, D. Olagnier, A. Hirsch, , F. Pessler

This paper shows NRF2 activators inhibit influenza A virus by blocking nuclear export of viral RNPs, independent of NRF2 signaling, through interaction with XPO1 and KEAP1.

bioRxiv · Jun 11, 2023Microbiology

Polyether ionophore antibiotics target drug-resistant clinical isolates, persister cells, and biofilms

M. Wollesen, K. Mikkelsen, M. S. Tvilum, M. Vestergaard, M. Wang, H. Ingmer, R. L. Meyer, T. B. Poulsen, T. Torring

This study compares nine polyether ionophores to identify those with promising antibiotic activity against drug-resistant clinical isolates, biofilms, and persister cells.

bioRxiv · Feb 13, 2023Microbiology

The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, are potent BACH1 inhibitors

L. Casares, R. Moreno, M. Higgins, S. D. Naidu, G. Neill, L. Cassin, A. E. Kiib, E. B. Svenningsen, T. Honda, T. B. Poulsen, A. T. Dinkova-Kostova, D. Olagnier, L. de la Vega

This study identifies CDDO-derivatives as BACH1 inhibitors, explaining their higher potency as HMOX1 inducers compared to CDDO.

bioRxiv · Oct 29, 2021 · PreprintCell Biology

Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

D. Olagnier, E. Farahani, J. Thyrsted, J. B. Cadanet, A. Herengt, M. Idorn, A. Hait, B. Hernaez, A. Knudsen, M. B. Iversen, M. Schilling, S. E. Jorgensen, M. Thomsen, L. Reinert, M. Lappe, , C. K. Holm

The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.

bioRxiv · Jul 16, 2020Microbiology

Ionophore antibiotic X-206 is a potent and selective inhibitor of SARS-CoV-2 infection in vitro

E. B. Svenningsen, J. T. Jensen, J. Blay-Cadanet, H. Liu, S. Lin, J. M. Villameriel, D. Olagnier, M. Idorn, S. R. Paludan, C. K. Holm, T. B. Poulsen

This study identifies X-206, a polyether ionophore antibiotic, as a potent and selective inhibitor of SARS-CoV-2 infection in vitro with high selectivity and sub-nM efficacy.

bioRxiv · Jun 14, 2020Pharmacology & Toxicology

Structure and function of the bacterial protein toxin phenomycin

B. K. Hansen, C. K. Larsen, J. T. Nielsen, E. B. Svenningsen, L. B. Van, K. M. Jacobsen, M. Bjerring, R. K. Flygaard, L. B. Jenner, L. N. Nejsum, D. E. Brodersen, F. A. A. Mulder, T. Toerring, T. B. Poulsen

This study investigates phenomycin's mechanism of toxicity, showing it inhibits translation initiation, requires endosomal escape for toxicity, and identifies a critical structural loop for its activity.

bioRxiv · Nov 29, 2019Cell Biology