Author

M. Hirota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Ecology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Mabuchi· 1 shared A. Toyoda· 1 shared C. Tei· 1 shared C. Yamashiro· 1 shared D. Kitagawa· 1 shared D. M. d. A. Pessoa· 1 shared E. Sakihara· 1 shared G. G. Grimaldi· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperCell Biology

A. Mabuchi

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Author profile →

4 papers

Recent·Most cited

Biofluorescence reveals hidden patterns in chitons with implications to visual ecology.

G. G. Grimaldi, R. d. S. Guidi, J. A. Jardim, M. Hirota, D. M. d. A. Pessoa, P. A. Horta

The paper documents biofluorescence in chitons, analyzes its spectral properties, and models its impact on predator detection.

bioRxiv · Sep 13, 2023 · PreprintEcology

Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity

M. Hirota, M. Tamai, S. Yukawa, N. Taira, M. M. Matthews, T. Toma, Y. Seto, M. Yoshida, S. Toguchi, M. Miyagi, T. Mori, H. Tomori, O. Tamai, M. Kina, E. Sakihara, , H. Ishikawa

The paper identifies baseline AP-1 gene expression and gut microbial fucose/rhamnose degradation as factors negatively correlated with BNT162b2 mRNA vaccine-induced T-cell responses.

bioRxiv · Aug 8, 2022 · PreprintImmunology

ssDNA is not superior to dsDNA as long HDR donors for CRISPR-mediated endogenous gene tagging in human diploid cells

A. Mabuchi, S. Hata, M. Genova, C. Tei, K. K. Ito, M. Hirota, T. Komori, M. Fukuyama, T. Chinen, A. Toyoda, D. Kitagawa

This study compares ssDNA and dsDNA as HDR donors for CRISPR-mediated gene tagging in human diploid cells, finding dsDNA more efficient for precise insertion.

bioRxiv · Jun 1, 2022 · PreprintCell Biology

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

T. Yamada, S. Hino, H. Iijima, T. Genda, R. Aoki, R. Nagata, H. Han, M. Hirota, Y. Kinashi, H. Oguchi, W. Suda, Y. Furusawa, Y. Fujimura, J. Kunisawa, M. Hattori, , K. Hase

This study identifies mucin O-glycans as a fermentation substrate for n-butyrate production, which supports immune homeostasis in the gut.

bioRxiv · May 30, 2019Microbiology