Author

H. Sasaki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 2 Microbiology· 2 Biophysics· 1 Pharmacology & Toxicology· 1

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:differential expression· 3 Assay:proteomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2

Frequent Co-Authors

A. Upadhyaya· 2 shared H. Shroff· 2 shared J. CheniD· 2 shared M. Guo· 2 shared M. Suzuki· 2 shared S.-J. J. Lee· 2 shared X. Li· 2 shared Y. Su· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

A. Upadhyaya

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10 papers

Recent·Most cited

Cellulose Rich Food Leads Anxiety through Gut-Brain Axis-mediated Amygdalar Dopamine Upregulation.

K. Ito, H. Hosoki, Y. Kasai, H. Sasaki, A. Haraguchi, S. Shibata, C. Nozaki

This study shows that a cellulose-rich diet increases anxiety in mice through gut-brain axis mechanisms involving amygdalar dopamine upregulation and opioidergic system activation.

bioRxiv · May 7, 2024 · PreprintPharmacology & Toxicology

Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms

M. Suzuki, S. Okamura, T. Gis, H. Sasaki, S. Lee, A. Yoshida, S. Goto, M. Matsumoto, M. Yamawaki, T. Miyazaki, T. Nakagawa, M. Ikawa, W. Kamitani, S. Takekawa, K. Yamanishi, H. Ebina

This study develops a live-attenuated SARS-CoV-2 vaccine candidate, BK2102, which induces long-term immunity and is safe in animal models.

bioRxiv · Mar 3, 2024Microbiology

Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells

N. Kubo, R. Uehara, S. Uemura, H. Ohishi, K. Shirane, H. Sasaki

This study examines the roles of ADD domains in DNMT3A and DNMT3L in DNA methylation in mouse germ cells, finding that their combined loss leads to severe methylation defects.

bioRxiv · Sep 7, 2023Cell Biology

Three-dimensional structured illumination microscopy with enhanced axial resolution

X. Li, Y. Wu, Y. Su, I. A. R. Suarez, C. Matthaeus, T. B. Updegrove, Z. Wei, L. Zhang, H. Sasaki, Y. Li, M. Guo, J. P. Giannini, H. D. Vishwasrao, J. Chen, S.-J. J. Lee, , H. Shroff

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

Nature Biotechnology · Jan 26, 2023Peer-reviewedCell Biology

Differential cellular stiffness contributes to tissue elongation on an expanding surface

H. Koyama, M. Suzuki, N. Yasue, H. Sasaki, N. Ueno, T. Fujimori

This study investigates how differential cellular stiffness, through area elasticity, influences tissue elongation in an expanding environment, supported by comparisons to mouse notochord development.

bioRxiv · Jan 27, 2022Biophysics

Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing

Y. Shibuya, A. Hokugo, H. Okawa, T. Kondo, D. Khalil, L. Wang, Y. Roca, A. Clements, H. Sasaki, E. Berry, I. Nishimura, R. Jarrahy

This study identifies a compound, Dwn1, that downregulates Npas2 and accelerates wound healing with reduced scarring in mice.

bioRxiv · Nov 29, 2021Bioengineering

Three-dimensional residual channel attention networks denoise and sharpen fluorescence microscopy image volumes

J. Chen, H. Sasaki, H. Lai, Y. Su, J. Liu, Y. Wu, A. Zhovmer, C. A. Combs, I. Rey-Suarez, H. Chang, C. C. Huang, X. Li, M. Guo, S. Nizambad, A. Upadhyaya, , H. Shroff

This paper applies RCAN to enhance fluorescence microscopy image volumes, achieving denoising and resolution improvements across multiple microscopy techniques.

Nature Methods · May 31, 2021Peer-reviewedBioengineering

Arf GTPase-Activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor

A. Watanabe, H. Hataida, N. Inoue, K. Kamon, K. Baba, K. Sasaki, R. Kimura, H. Sasaki, Y. Eura, W.-F. Ni, Y. Shibasaki, S. Waguri, K. Kokame, y. shiba

This study identifies SMAP1 and AGFG2 as ArfGAPs regulating Weibel-Palade body size and von Willebrand factor exocytosis, respectively.

bioRxiv · Mar 29, 2021Cell Biology

Identification of differential gene expression pattern in lens epithelial cells derived from cataractous and non-cataractous lenses of Shumiya cataract rat

H. Ishida, T. Shibata, Y. Nakamura, Y. Ishigaki, H. Sasaki, D. P. Singh, E. Kubo

This study identifies gene expression changes in lens epithelial cells of Shumiya cataract rats, finding downregulation of genes involved in fiber differentiation and suggesting cholesterol deficiency contributes to cataract formation.

bioRxiv · May 19, 2020Cell Biology

A survey of vaccine-induced measles IgG antibody titer and the verification of changes in temporal differences of measles vaccination in young adults

H. Sasaki, T. Fukunaga, A. Asano, Y. Suzuki, Y. Nakanishi, J. Kondo, H. Ishikawa, N. Shibata

This study examines measles IgG antibody titers in young adults and finds that antibody levels correlate with medical history and time since last vaccination, suggesting the need for periodic measles vaccination.

bioRxiv · May 10, 2019Microbiology