Author

T. M. Clausen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

D. R. Sandoval· 3 shared J. D. Esko· 3 shared B. P. Kellman· 2 shared C. Martino· 2 shared Y. Zhang· 2 shared A. B. Ward· 1 shared A. D. Swafford· 1 shared A. F. Carlin· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMicrobiology

D. R. Sandoval

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

S. B. Biering, F. Tramontini Gomes de Sousa, L. V. Tjang, F. Pahmeier, R. Ruan, S. F. Blanc, T. S. Patel, C. M. Worthington, D. R. Glasner, B. Castillo-Rojas, V. Servellita, N. T. Lo, M. P. Wong, C. M. Warnes, D. R. Sandoval, , E. Harris

This study shows SARS-CoV-2 Spike protein causes barrier dysfunction and vascular leak through integrins and TGF-β signaling, independent of viral replication and ACE2.

bioRxiv · Dec 10, 2021 · PreprintMicrobiology

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

T. M. Clausen, D. R. Sandoval, C. B. Spliid, J. Pihl, C. D. Painter, B. E. Thacker, C. A. Glass, A. Narayanan, S. A. Majowicz, Y. Zhang, J. L. Torres, G. J. Golden, R. Porell, A. F. Garretson, L. Laubach, , J. D. Esko

This study shows SARS-CoV-2 spike protein binds to heparan sulfate and ACE2 on cells codependently, forming a complex that facilitates infection, suggesting potential therapeutic targets.

Cell · Nov 1, 2020Peer-reviewedMicrobiology

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

C. Martino, B. P. Kellman, D. R. Sandoval, T. M. Clausen, C. A. Marotz, S. J. Song, S. Wandro, L. S. Zaramela, R. A. Salido Benitez, Q. Zhu, E. Armingol, Y. Vazquez-Baeza, D. McDonald, J. T. Sorrentino, B. Taylor, , R. Knight

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.

bioRxiv · Aug 17, 2020 · PreprintMicrobiology