Author

T. Maruno

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Assay:structural biology· 1

Frequent Co-Authors

S. Uchiyama· 3 shared A. Yui· 2 shared D. Kuroda· 2 shared K. Tsumoto· 2 shared M. Nakakido· 2 shared S. Nagatoishi· 2 shared C. Aguirre· 1 shared C.-J. Choong· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

S. Uchiyama

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene

A. Yui, D. Kuroda, T. Maruno, M. Nakakido, S. Nagatoishi, S. Uchiyama, K. Tsumoto

This study investigates how SNPs in the LI-cadherin gene affect cancer metastasis by weakening cell-cell adhesion through reduced homodimerization and altered hydrogen bonding.

bioRxiv · Oct 2, 2022 · PreprintBiochemistry

Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs

C. Aguirre, Y. Miyanoiri, M. So, H. Tamaki, T. Maruno, J. Doi, N. Wang, K. Yamaguchi, K. Nakajima, Y. Yamamori, H. Inoura, C.-J. Choong, K. Kakuda, T. Ajiki, Y. Kimura, , H. Mochizuki

This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.

bioRxiv · Feb 10, 2022 · PreprintBiophysics

Dimerization mechanism and structural features of human LI-cadherin

A. Yui, J. M. M. Caaveiro, D. Kuroda, M. Nakakido, S. Nagatoishi, S. Goda, T. Maruno, S. Uchiyama, K. Tsumoto

This study determines the crystal structure of LI-cadherin EC1-4 homodimer and shows its unique architecture and noncanonical calcium ion-free linker, revealing the mechanism of homodimerization essential for cell adhesion.

bioRxiv · Sep 18, 2020Biochemistry