Author

T. N. Denny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 4 Organism:non-human primate· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

B. F. Haynes· 4 shared C. T. DeMarco· 4 shared D. C. Montefiori· 4 shared D. Li· 4 shared D. R. Martinez· 4 shared E. Lee· 4 shared K. Mansouri· 4 shared L. L. Sutherland· 4 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

B. F. Haynes

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

R. D. Malewana, V. Stalls, A. May, X. Lu, D. R. Martinez, A. Schafer, D. Li, M. Barr, L. L. Sutherland, E. Lee, R. Parks, W. E. Beck, A. Newman, K. W. Bock, M. Minai, , K. O. Saunders

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

bioRxiv · Dec 18, 2023 · PreprintImmunology

Mapping SARS-CoV-2 antigenic relationships and serological responses

S. H. Wilks, B. Muhlemann, X. Shen, S. Tureli, E. B. LeGresley, A. Netzl, M. A. Caniza, J. N. Chacaltana-Huarcaya, V. M. Corman, X. Daniell, M. B. Datto, F. S. Dawood, T. N. Denny, C. Drosten, R. A. M. Fouchier, , D. J. Smith

The paper uses antigenic cartography to analyze cross-reactivity among SARS-CoV-2 variants and human sera, identifying amino acid substitutions and immunodominance patterns affecting immune escape and vaccine efficacy.

bioRxiv · Jan 28, 2022Immunology

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

D. Li, D. R. Martinez, A. Schäfer, H. Chen, M. Barr, L. L. Sutherland, E. Lee, R. Parks, D. Mielke, W. Edwards, A. Newman, K. W. Bock, M. Minai, B. M. Nagata, M. Gagne, , B. F. Haynes

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

bioRxiv · Jan 26, 2022Immunology

SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys

K. O. Saunders, E. Lee, R. Parks, D. R. Martinez, D. Li, H. Chen, R. J. Edwards, S. M. C. Gobeil, M. Barr, K. Mansouri, S. M. Alam, L. L. Sutherland, F. Cai, A. Sanzone, M. Berry, , B. F. Haynes

This study shows that SARS-CoV-2 vaccines induce neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, and batCoVs in monkeys.

bioRxiv · Feb 17, 2021 · PreprintImmunology

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure

H. Li, S. Wang, F.-H. Lee, R. S. Roark, A. I. Murphy, J. Smith, C. Zhao, J. Rando, N. Chohan, Y. Ding, E. Kim, E. Lindemuth, K. J. Bar, I. Pandrea, C. Apetrei, , G. M. Shaw

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

bioRxiv · Jan 13, 2021Microbiology

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

D. Li, R. J. Edwards, K. Manne, D. R. Martinez, A. Schafer, S. M. Alam, K. Wiehe, X. Lu, R. Parks, L. L. Sutherland, T. H. Oguin, C. McDanal, L. G. Perez, K. Mansouri, S. M. C. Gobeil, , Petzol

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

bioRxiv · Dec 31, 2020 · PreprintImmunology

Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19

C. Yu, S. Littleton, N. Giroux, R. Mathew, S. Ding, J. Kalnitsky, E. Petzold, H. Chung, G. r. Palomino, T. Rotstein, R. Xi, E. R. Ko, E. L. Tsalik, g. sempowski, T. N. Denny, , D. R. Saban

The paper examines sex differences in MAIT cell responses in COVID-19 patients, finding reduced circulating MAIT cells in females and a protective gene signature associated with female MAIT cells.

bioRxiv · Dec 1, 2020Immunology