Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress Survival
Athena L. Munden, Dominique S. Lui, Daniel P Higgins, Matthew J. Fanelli, Thien-Kim Ngyuen, Katherine M. Edwards, Maria Ericsson, Adwait Anand Godbole, John D. Haley, Caroline A. Lewis, Jessica B. Spinelli, Benjamin R. Harrison, Daniel Raftery, Danijel Djukovic, Daniel Promislow, , Amy Karol Walker
The paper investigates the functional specialization of SAM synthases in C. elegans, showing that SAMS-1 affects mitochondrial function and stress survival through phosphatidylcholine, while SAMS-4 is critical for methylation reactions.
bioRxiv · Feb 20, 2025 · PreprintCell Biology