RNA-binding proteins control the G2-M checkpoint of the germinal centre B cell
Fiamma Salerno, Alex J. Whale, Louise S. Matheson, Davide Maria Vespasiani, William S. Foster, Twm J. Mitchell, Michael Screen, Melanie Stammers, Sarah E. Bell, Daniel James Hodson, Hamish W. King, Michelle A. Linterman, Jonathan M. Houseley, Martin Turner
This study identifies ZFP36L1 and ZFP36L2 as RNA-binding proteins that regulate the G2-M checkpoint in GC B cells to prevent replication stress and maintain genome stability.
Science Immunology · Oct 31, 2025Peer-reviewedImmunology