A bioenergetic basis for multiorgan dysfunction in sepsis
Elisa Jentho, Temitope Wilson Ademolue, Hessel Peters Sengers, Joe M. Butler, Linlin Xu, Sharad Rastogi, Jamil Zola Kitoko, Sara Emanuela Pagnotta, Bernhard Drotleff, Pedro Faísca, Valentyna O. Polishchuk, Miguel Mesquita, Paul Horn, Uta Barbara Metzing, Sílvia Cardoso, , Miguel Parreira Soares
This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.
bioRxiv · Jun 12, 2025 · PreprintPathology