Victor X. Jin

TAOK3 inhibition constrains invasion, potentiates paclitaxel, and reprograms the tumor microenvironment toward anti-tumor immunity in cervical cancer

This study shows TAOK3 inhibition reduces cervical cancer invasion, increases paclitaxel sensitivity, and promotes anti-tumor immunity by altering the tumor microenvironment.

EZH2 Inhibition Reshapes 3D Chromatin Architecture to Induce Immunogenic Phenotype in Small Cell Lung Cancer

This study shows that inhibiting EZH2 alters 3D chromatin structure in SCLC, reactivating MHC genes and enhancing immunogenicity.

Decreased endothelial cell retinoic acid signaling accelerates progression of single ventricle pulmonary arteriovenous malformations

This study uses scRNA-seq to identify decreased retinoic acid signaling in endothelial cells post-Glenn surgery, linking it to accelerated PAVM progression and suggesting dietary vitamin A modification as a potential therapeutic strategy.

Novel Spatial-Structural-Zero-Aware Dissimilarity Measures for Subtype Discovery Using Single Cell Hi-C Data

This study introduces szKendall, a dissimilarity measure for scHi-C data that accounts for structural zeros, improving cell clustering performance.

Nuc3DMap delineates finer nucleosome-based three-dimensional chromatin architecture

Nuc3DMap integrates MNase-seq, Hi-C, and Micro-C data to delineate finer nucleosome-based 3D chromatin architecture and identifies distinct subtypes of chromatin features.

Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity and tumor-specific looping-mediated biological pathways

The paper uses Hi-C profiling in breast tissues to reveal 3D chromatin-regulated tumor heterogeneity and identifies CA2 as a driver of tamoxifen resistance through enhancer-promoter looping.

Integration of scHi-C and scRNA-seq data defines distinct 3D-regulated and biological-context dependent cell subpopulations

The paper integrates scHi-C and scRNA-seq data to identify 3D-regulated cell subpopulations in breast cancer, revealing new chromatin structures and biological contexts.

EHMT2 Inactivation in Pancreatic Epithelial Cells Shapes the Transcriptional Landscape and Inflammation Response of the Whole Pancreas

HiCImpute: A Bayesian Hierarchical Model for Identifying Structural Zeros and Enhancing Single Cell Hi-C Data.

HiCImpute identifies structural zeros in scHi-C data and improves imputation, leading to more accurate clustering and subtype discovery in neuronal cells.