The paper identifies genetic loci associated with variability in brain volumes and thickness, showing they are distinct from loci affecting mean volumes.

Molecular Psychiatry · Feb 11, 2020Peer-reviewedNeuroscience

Genetics of brain age suggest an overlap with common brain disorders

Tobias Kaufmann, Dennis van der Meer, Nhat Trung Doan, Emanuel Schwarz, Martina Jonette Lund, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur‐Streubel, Alessandro Bertolino, Francesco Bettella, Mona Kristiansen Beyer, Erlend Bøen, Stefan Borgwardt, Christine Lycke Brandt, , Neurocognition and Genetics Study for the Pediatric Imaging

The paper estimates brain age gaps using MRI and machine learning in individuals with and without brain disorders, finding heritability and genetic overlap with common disorders.

Nature Neuroscience · Sep 24, 2019Peer-reviewedNeuroscience

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

Max Lam, William David Hill, Joey W. Trampush, Jin Yu, Emma Knowles, Gail Davies, Eli A. Stahl, Laura M. Huckins, David C M Liewald, Srdjan Djurovic, Ingrid Melle, Kjetil S. Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, , Todd Lencz

The paper uses pleiotropic meta-analysis to identify genetic loci associated with cognition, education, and schizophrenia, revealing distinct biological mechanisms for concordant and discordant genetic correlations.

The American Journal of Human Genetics · Aug 1, 2019Peer-reviewedGenetics

Analysis of differentially methylated regions in primates and non-primates provides support for the evolutionary hypothesis of schizophrenia

Niladri Banerjee, Tatiana V. Polushina, Francesco Bettella, Vidar M. Steen, Ole A. Andreassen, Stéphanie Le Hellard

The paper analyzes differentially methylated regions in primates and non-primates to test the evolutionary hypothesis of schizophrenia, finding limited enrichment of schizophrenia associations in primate DMRs.

Schizophrenia Research · Dec 11, 2018Peer-reviewedGenomics

Brain scans from 21297 individuals reveal the genetic architecture of hippocampal subfield volumes

Alzheimer’s Disease Neuroimaging Initiative, Dennis van der Meer, for the Pediatric Imaging, Neurocognition and Genetics Study, Jaroslav Rokicki, Tobias Kaufmann, Aldo Córdova‐Palomera, Torgeir Moberget, Dag Alnæs, Francesco Bettella, Oleksandr Frei, Nhat Trung Doan, Ida Elken Sønderby, Olav Bjerkehagen Smeland, Ingrid Agartz, Alessandro Bertolino, , Lars Tjelta Westlye

This study identifies 15 genome-wide significant loci associated with hippocampal subfield volumes in 21,297 individuals, revealing distinct genetic determinants for different subfields.

Molecular Psychiatry · Oct 2, 2018Peer-reviewedGenetics

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

Jeanne E. Savage, Philip R. Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B. Barr, Jonathan R. I. Coleman, Katrina L. Grasby, Anke R. Hammerschlag, Jakob André Kaminski, Robert Karlsson, Eva M. L. Krapohl, , Lene Christiansen

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

Nature Genetics · Jun 25, 2018Peer-reviewedGenetics